Phenotypes associated with this allele

• Allele Symbol: Mir205^tm1.2Mtm
• Allele Name: targeted mutation 1.2, Michael McManus
• Allele ID: MGI:5568716
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir205^tm1.2Mtm/Mir205^tm1.2Mtm	B6.129P2(Cg)-Mir205^tm1.2Mtm	MGI:5568722

Genotype
MGI:5568722

hm1

• Allelic Composition: Mir205^tm1.2Mtm/Mir205^tm1.2Mtm
• Genetic Background: B6.129P2(Cg)-Mir205^tm1.2Mtm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and skin defects in P10 Mir205^tm1.2Mtm/Mir205^tm1.2Mtm mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:209028 )

• within the first 2 weeks of birth

integument

integument phenotype ( J:209028 )

N • early follicle development is intact

dry skin ( J:209028 )

thin skin ( J:209028 )

abnormal skin development ( J:209028 )

• irregular skin development

• however, skin barrier at E18.5 and P1 is normal

growth/size/body

decreased body size ( J:209028 )

• at P10

decreased body weight ( J:209028 )

• especially in mice that die postnatally