Mir205tm1.2Mtm
Targeted Allele Detail
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Symbol: |
Mir205tm1.2Mtm |
Name: |
microRNA 205; targeted mutation 1.2, Michael McManus |
MGI ID: |
MGI:5568716 |
Gene: |
Mir205 Location: Chr1:193189771-193189838 bp, - strand Genetic Position: Chr1, 97.82 cM
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Alliance: |
Mir205tm1.2Mtm page
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Small size and skin defects in P10 Mir205tm1.2Mtm/Mir205tm1.2Mtm mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:209028
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to insert an FRT site followed by a lacZ gene, a loxP site, a neomycin cassette, an FRT site and a loxP site (FRT-lacZ-loxP-Neo-FRT-loxP) upstream of the microRNA stem loop and one loxP site immediately downstream of the microRNA stem loop. Flp-mediated recombination removed the reporter and selection cassettes. Cre-mediated recombination removed the microRNA sequence.
(J:209028)
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Generation of the Mir205tm1Mtm, Mir205tm1.1Mtm, and Mir205tm1.2Mtm alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mir205 Mutation: |
3 strains or lines available
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Original: |
J:209028 Farmer DT, et al., Partially penetrant postnatal lethality of an epithelial specific MicroRNA in a mouse knockout. PLoS One. 2013;8(10):e76634 |
All: |
2 reference(s) |
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