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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-Jtm2.1(4E10)Lave
targeted mutation 2.1, Laurent Verkoczy
MGI:5550246
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igh-Jtm2.1(4E10)Lave/Igh-Jtm2.1(4E10)Lave involves: C57BL/6 MGI:5550249
cx2
 		Igh-Jtm2.1(4E10)Lave/Igh-Jtm2.1(4E10)Lave
Igk-Jtm2.1(4E10)Lave/Igk-Jtm2.1(4E10)Lave 		involves: C57BL/6 MGI:5550252


Genotype
MGI:5550249
hm1
Allelic
Composition		 Igh-Jtm2.1(4E10)Lave/Igh-Jtm2.1(4E10)Lave
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm2.1(4E10)Lave mutation (0 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested B cell differentiation ( J:205708 )
• B cell development is blocked at the small pre-B to immature B transition

hematopoietic system
arrested B cell differentiation ( J:205708 )
• B cell development is blocked at the small pre-B to immature B transition




Genotype
MGI:5550252
cx2
Allelic
Composition		 Igh-Jtm2.1(4E10)Lave/Igh-Jtm2.1(4E10)Lave
Igk-Jtm2.1(4E10)Lave/Igk-Jtm2.1(4E10)Lave
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm2.1(4E10)Lave mutation (0 available); any Igh-J mutation (13 available)
Igk-Jtm2.1(4E10)Lave mutation (0 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:205708 )
• modest blockage at the pro/large pre-B to small pre-B transition
arrested B cell differentiation ( J:205708 )
• B cell development is blocked at the small pre-B to immature B transition
abnormal B cell physiology ( J:205708 )
• B cells exhibit elevated basal activation and muted response to BCR ligation

hematopoietic system
abnormal B cell differentiation ( J:205708 )
• modest blockage at the pro/large pre-B to small pre-B transition
arrested B cell differentiation ( J:205708 )
• B cell development is blocked at the small pre-B to immature B transition
abnormal B cell physiology ( J:205708 )
• B cells exhibit elevated basal activation and muted response to BCR ligation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory