Phenotypes associated with this allele

• Allele Symbol: Rnf7^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5545787
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf7^tm1c(EUCOMM)Wtsi/Rnf7^tm1c(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5545903
cn2	Rnf7^tm1c(EUCOMM)Wtsi/Rnf7^tm1c(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5545904
cn3	Dab1^tm1Cpr/Dab1^tm1Cpr Rnf7^tm1c(EUCOMM)Wtsi/Rnf7^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL	MGI:5545906
cn4	Dab1^tm1Cpr/Dab1^+ Rnf7^tm1c(EUCOMM)Wtsi/Rnf7^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL	MGI:5545907
cn5	Rnf7^tm1c(EUCOMM)Wtsi/Rnf7^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:5545905

Genotype
MGI:5545903

hm1

• Allelic Composition: Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205551 )

• mice are viable and fertile

Genotype
MGI:5545904

cn2

• Allelic Composition: Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

nervous system

abnormal neuronal migration ( J:205551 )

• following in utero cre electroporation, E14.5 neurons exhibit cell autonomous over-migration compared with control mice

cellular

abnormal neuronal migration ( J:205551 )

• following in utero cre electroporation, E14.5 neurons exhibit cell autonomous over-migration compared with control mice

Genotype
MGI:5545906

cn3

• Allelic Composition: Dab1^tm1Cpr/Dab1^tm1Cpr; Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

nervous system

abnormal cortical marginal zone morphology ( J:205551 )

• absent as in Dab1^tm1Cpr homozygotes

abnormal cortical plate morphology ( J:205551 )

• inverted cortical plate as in Dab1^tm1Cpr homozygotes

abnormal cerebellum development ( J:205551 )

• underdeveloped as in Dab1^tm1Cpr homozygotes

Genotype
MGI:5545907

cn4

• Allelic Composition: Dab1^tm1Cpr/Dab1⁺; Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

nervous system

nervous system phenotype ( J:205551 )

N • Purkinje cell positioning and cerebellum size are rescued compared to in Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln mice

Genotype
MGI:5545905

cn5

• Allelic Composition: Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

nervous system

decreased cerebellar granule cell precursor proliferation ( J:205551 )

• fewer mitotic granule cell in the cerebellum at P5

hydrocephaly ( J:205551 )

• progressive in most mice by 3 to 6 months

enlarged brain ventricles ( J:205551 )

• in most mice at P10 to P15

abnormal cerebellar layer morphology ( J:205551 )

• ectopic lamination at E17.5

• intermingling layers at P5

ectopic Purkinje cell ( J:205551 )

• at E17.5

• in the white matter at P5

delaminated Purkinje cell layer ( J:205551 )

• at P5

small cerebellum ( J:205551 )

• reduced area at P5

growth/size/body

postnatal growth retardation ( J:205551 )

• mice fail to thrive

cellular

decreased cerebellar granule cell precursor proliferation ( J:205551 )

• fewer mitotic granule cell in the cerebellum at P5