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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2-Ab1tm1Wug
targeted mutation 1, Gregory F Wu
MGI:5543894
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2-Ab1tm1Wug/H2-Ab1tm1Wug involves: C57BL/6 MGI:5543896
cn2
H2-Ab1tm1Wug/H2-Ab1tm1Wug
Cd19tm1(cre)Cgn/Cd19+
involves: 129S2/SvPas * C57BL/6 MGI:5543897


Genotype
MGI:5543896
hm1
Allelic
Composition
H2-Ab1tm1Wug/H2-Ab1tm1Wug
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Wug mutation (0 available); any H2-Ab1 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cells fail to prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation unlike wild-type cells
• bone marrow-derived dendritic cells fail to generate an antigen-specific response unlike wild-type cells

hematopoietic system
• B cells fail to prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation unlike wild-type cells




Genotype
MGI:5543897
cn2
Allelic
Composition
H2-Ab1tm1Wug/H2-Ab1tm1Wug
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
H2-Ab1tm1Wug mutation (0 available); any H2-Ab1 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal B cell development
• B cells prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation to a lesser extent than wild-type cells
• bone marrow-derived dendritic cells fail to generate an antigen-specific response unlike wild-type cells

hematopoietic system
• B cells prime MOG-specific 2D2 TCR transgenic CD4 T cell proliferation to a lesser extent than wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory