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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Asah1tm1.1Jhkh
targeted mutation 1.1, Johannes Kornhuber
MGI:5523898
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Asah1tm1.1Jhkh/Asah1tm1.1Jhkh Not Specified MGI:5523917
cx2
 		Asah1tm1.1Jhkh/Asah1+
Smpd1tm1Esc/Smpd1+ 		involves: 129S1/Sv MGI:5523918


Genotype
MGI:5523917
hm1
Allelic
Composition		 Asah1tm1.1Jhkh/Asah1tm1.1Jhkh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asah1tm1.1Jhkh mutation (0 available); any Asah1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal ceramide level ( J:199833 )
• very high constitutive hippocampal ceramide concentrations
• however, concentrations are reduced by antidepressants
abnormal physiological response to xenobiotic ( J:199833 )
• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine
• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival
• however, treatment with antidepressants or fendiline normalizes behavior in corticosterone stressed or nonstressed mice

behavior/neurological
abnormal depression-related behavior ( J:199833 )
• mice exhibit depression-like behavior
• however, treatment with antidepressants or fendiline normalizes behavior in corticosterone stressed or nonstressed mice

nervous system
abnormal neuron differentiation ( J:199833 )
• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine
• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival

cellular
abnormal neuron differentiation ( J:199833 )
• decreased neurogenesis, neuronal maturation and survival in the absence or presence of amitriptyline and fluoxetine
• however, corticosterone stressed or nonstressed mice treated with amitriptyline and fluoxetine exhibit increased in neurogenesis, neuronal maturation and survival




Genotype
MGI:5523918
cx2
Allelic
Composition		 Asah1tm1.1Jhkh/Asah1+
Smpd1tm1Esc/Smpd1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asah1tm1.1Jhkh mutation (0 available); any Asah1 mutation (37 available)
Smpd1tm1Esc mutation (0 available); any Smpd1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal depression-related behavior ( J:199833 )
• the increased in depression-like behavior observed in Asah1tm1.1Jhkh homozygotes is normalized

cellular
abnormal neuron differentiation ( J:199833 )
• the decreased neurogenesis and neuronal maturation observed in Asah1tm1.1Jhkh homozygotes is normalized but is increased compared to in wild-type mice

homeostasis/metabolism
abnormal ceramide level ( J:199833 )
• high constitutive hippocampal ceramide concentrations compared with wild-type mice

nervous system
abnormal neuron differentiation ( J:199833 )
• the decreased neurogenesis and neuronal maturation observed in Asah1tm1.1Jhkh homozygotes is normalized but is increased compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory