Phenotypes associated with this allele

• Allele Symbol: Adgrg6^tm1Taki
• Allele Name: targeted mutation 1, Tetsu Akiyama
• Allele ID: MGI:5521368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrg6^tm1Taki/Adgrg6^tm1Taki	involves: C57BL/6	MGI:5523456

Genotype
MGI:5523456

hm1

• Allelic Composition: Adgrg6^tm1Taki/Adgrg6^tm1Taki
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hypotrabeculation and thinner ventricular myocardium in Adgrg6^tm1Taki/Adgrg6^tm1Taki embryonic hearts

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:202002 )

• die between E11.5 and E13.5

cellular

abnormal mitochondrial morphology ( J:202002 )

• electron-dense precipitates are seen in cardiomyocytes and endocardial cells

abnormal fetal cardiomyocyte mitochondrial morphology ( J:202002 )

• mitochondria in endocardial cells display a more complex shape, less well developed cristae and electron dense precipitates

abnormal mitochondrial crista morphology ( J:202002 )

• less well developed cristae in cardiomyocytes and endocardial cells

abnormal mitochondrial shape ( J:202002 )

• more complex shape in cardiomyocytes and endocardial cells

homeostasis/metabolism

increased cardiac muscle triglyceride level ( J:202002 )

• triglyceride accumulation in cardiac cells

pericardial edema ( J:202002 )

• at E11.25, mild

muscle

increased cardiac muscle triglyceride level ( J:202002 )

• triglyceride accumulation in cardiac cells

abnormal myocardial trabeculae morphology ( J:202002 )

• fewer trabeculae

cardiovascular system

cardiovascular system phenotype ( J:202002 )

N • no defects in cell-cell contacts detected in the heart

increased cardiac muscle triglyceride level ( J:202002 )

• triglyceride accumulation in cardiac cells

abnormal myocardial trabeculae morphology ( J:202002 )

• fewer trabeculae

abnormal fetal cardiomyocyte morphology ( J:202002 )

• large numbers of lipid droplets accumulate

abnormal fetal cardiomyocyte mitochondrial morphology ( J:202002 )

• mitochondria in endocardial cells display a more complex shape, less well developed cristae and electron dense precipitates

abnormal endocardium morphology ( J:202002 )

• mitochondria display a more complex shape, less well developed cristae and electron dense precipitates

• large numbers of lipid droplets accumulate

thin ventricular wall ( J:202002 )

pericardial edema ( J:202002 )

• at E11.25, mild