Adgrg6^tm1Taki
Targeted Allele Detail

Summary

• Symbol: Adgrg6^tm1Taki
• Name: adhesion G protein-coupled receptor G6; targeted mutation 1, Tetsu Akiyama
• MGI ID: MGI:5521368
• Synonyms: R-Gpr126-
• Gene: Adgrg6 Location: Chr10:14278327-14421403 bp, - strand Genetic Position: Chr10, 5.43 cM
• Alliance: Adgrg6^tm1Taki page

Hypotrabeculation and thinner ventricular myocardium in Adgrg6^tm1Taki/Adgrg6^tm1Taki embryonic hearts

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202002
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 has been replaced by a NLS-LacZ cassette and a loxP flanked neo cassette. RT-PCR analysis confrimed the absence of mRNA expression in hearts from homozygous mice. (J:202002)

Generation of the Adgrg6^tm1Taki allele

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrg6 Mutation: 63 strains or lines available

References

• Original: J:202002 Patra C, et al., Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16898-903
• All: 1 reference(s)