Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2c2tm1Bbm mutation
(0 available);
any
Nr2c2 mutation
(67 available)
Tg(Camk2a-cre)#Stl mutation
(0 available)
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integument
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N |
• mice exhibit normal pain and itch behaviors
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nervous system
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N |
• mice exhibit normal spinal cord organization
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2c2tm1Bbm mutation
(0 available);
any
Nr2c2 mutation
(67 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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behavior/neurological
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N |
• mice exhibit normal performance in the Morris Water Maze and the open field test
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• mice exhibit a small increase in the time spent in the open arms of a zero maze compared with wild-type mice
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• mice exhibit impaired performance on a ledge test compared with wild-type mice
• however, mice exhibit normal performance on a rotarod unlike Nr2c2tm1Chc homozygotes
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• following nerve-injury induced persistent pain, mice exhibit less mechanical hyperalegsia with greater sensitized threshold compared with wild-type mice
• in a model of nerve injury-induced neuropathic pain or in the spared nerve injury model of neuropathic pain, mice exhibit a decreased magnitude of thermal hyperalgesia with absent mechanical hyperalgesia compared with wild-type mice
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• in response to capsaicin or formalin
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• mice exhibit increased reflex withdrawal thresholds in the von Frey test of mechanical pain compared with wild-type mice
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• mice exhibit high response latencies in a hot plate test compared with wild-type mice
• however, mice exhibit normal response in the Hargreaves and tail immersion reflex withdrawal tests
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nervous system
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• alteration of primary afferent terminations in the dorsal horn
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• neuronal loss in the superficial dorsal horn
• selective loss of excitatory neurons in the superficial dorsal horn
• however, projection neurons are spared
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• mice exhibit decreased noxious stimulus-induced responsiveness of presumptive dorsal horn projection neurons compared with wild-type mice
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growth/size/body
integument
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• puritogen-induced itch is absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2c2tm1Bbm mutation
(0 available);
any
Nr2c2 mutation
(67 available)
Tg(Nr5a1-cre)#Lowl mutation
(0 available)
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integument
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N |
• mice exhibit normal pain and itch behaviors
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nervous system
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N |
• mice exhibit normal spinal cord organization
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2c2tm1Bbm mutation
(0 available);
any
Nr2c2 mutation
(67 available)
Pax3tm1(cre)Joe mutation
(1 available);
any
Pax3 mutation
(50 available)
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integument
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• puritogen-induced itch is absent
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nervous system
behavior/neurological
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• in response to formalin
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• mice exhibit increased reflex withdrawal thresholds in the von Frey test of mechanical pain compared with wild-type mice
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• mice exhibit high response latencies in a hot plate test compared with wild-type mice
• however, mice exhibit normal response in the Hargreaves and tail immersion reflex withdrawal tests
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Analysis Tools