Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2cGt(P9-3F)Sor mutation
(0 available);
any
Ark2c mutation
(11 available)
Smad9tm1Rob mutation
(2 available);
any
Smad9 mutation
(32 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• fewer than expected mice survive prior to weaning
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• fewer than expected mice are born
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muscle
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• unilateral penetrance in the muscles controlling the digits and wrist
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behavior/neurological
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• some mice exhibit reduced hang time from a cage lid compared with wild-type mice
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nervous system
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• reduction or loss of the most distal innervation in the forelimbs
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skeleton
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• as in Rnf165 homozygotes
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limbs/digits/tail
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• as in Rnf165 homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2cGt(P9-3F)Sor mutation
(0 available);
any
Ark2c mutation
(11 available)
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• fewer than expected mice are born
• however, all born mice survive to adulthood
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nervous system
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• some mice exhibit innervation defects in the dorsal forelimb
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behavior/neurological
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• some mice exhibit reduced hang time from a cage lid compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2cGt(P9-3F)Sor mutation
(0 available);
any
Ark2c mutation
(11 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• all mice die within the first 3 postnatal weeks
• however, some mice survive beyond weaning one an unspecified mixed background
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nervous system
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• lateral motor column specification is normal
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• at E11.5, more dorsal radial and median nerves are reduced in length and width without compensatory increase in the size of the more ventral ulnar or thoracodorsal nerves compared to in wild-type mice
• at E12.5, radial nerves are thin and axons do not reach the more distal dorsal target muscles
• impaired motor axon extension in the dorsal forelimb
• however, no misrouting is observed
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• at E13.5, mice exhibit dorsal muscle innervation to varying degrees with increased severity towards the distal muscles controlling digits compared with wild-type mice
• however, forelimb innervation at E11.5 is normal
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• increased phrenic nerve synapses with reduced synaptic band width within the diaphragm at E18.5
• reduced individual axon length form the phrenic nerve to the synapse at E18 and P17
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homeostasis/metabolism
growth/size/body
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• 50% of normal at P15
• however, body size is normal at E18.5
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• newborns fail to grow and thrive
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limbs/digits/tail
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• reduced mean foot length due to reduced tor extension
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• atrophy of forelimb muscles that control forepaw and digit movement
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behavior/neurological
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• empty stomach and gut in postnatal mice at death
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• reduced hang time from a cage lid
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muscle
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• bilateral atrophy of forelimb muscles that control forepaw and digit movement
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cellular
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• at E11.5, more dorsal radial and median nerves are reduced in length and width without compensatory increase in the size of the more ventral ulnar or thoracodorsal nerves compared to in wild-type mice
• at E12.5, radial nerves are thin and axons do not reach the more distal dorsal target muscles
• impaired motor axon extension in the dorsal forelimb
• however, no misrouting is observed
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skeleton
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• mice are born with relaxed forepaws and reduced dorsioflexion
• at P21 and 3 to 6 months, mice on an unspecified mixed background are unable to extend and spread forepaw digits
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Analysis Tools