Phenotypes associated with this allele

• Allele Symbol: Rgs13^tm1.1Jhk
• Allele Name: targeted mutation 1.1, John H Kehrl
• Allele ID: MGI:5514157
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs13^tm1.1Jhk/Rgs13^tm1.1Jhk	involves: C57BL/6	MGI:5514165

Genotype
MGI:5514165

hm1

• Allelic Composition: Rgs13^tm1.1Jhk/Rgs13^tm1.1Jhk
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Large germinal centers in Rgs13^tm1.1Jhk/Rgs13^tm1.1Jhk mice

immune system

immune system phenotype ( J:199530 )

N • B cells exhibit normal proliferation in vitro

abnormal B cell differentiation ( J:199530 )

• in the bone marrow

decreased B cell number ( J:199530 )

• in the bone marrow

increased B cell number ( J:199530 )

• in Peyer's patches

increased germinal center B cell number ( J:199530 )

• in the Peyer's patch and mesenteric lymph nodes before and after immunization with sheep red blood cell

• in peripheral lymph nodes after immunization with sheep red blood cell

abnormal spleen morphology ( J:199530 )

• less distinct light zone and dark zone regions in the spleen of mice immunized with sheep red blood cell

increased spleen germinal center number ( J:199530 )

• in sheep red blood cell immunized mice

increased spleen germinal center size ( J:199530 )

• in sheep red blood cell immunized mice

abnormal humoral immune response ( J:199530 )

• mice immunized with sheep red blood cell generate more antibody secreting cells and IgG secreting B cells compared with wild-type mice

increased IgA level ( J:199530 )

• in mice immunized with sheep red blood cell

increased IgG1 level ( J:199530 )

• in mice immunized with sheep red blood cell

increased IgG2b level ( J:199530 )

• in mice immunized with TNP-KLH or sheep red blood cell

increased IgG2c level ( J:199530 )

• in mice immunized with TNP-KLH or sheep red blood cell

increased IgG3 level ( J:199530 )

• in mice immunized with TNP-KLH or sheep red blood cell

increased IgM level ( J:199530 )

• slight in mice immunized with TNP-KLH or sheep red blood cell

hematopoietic system

abnormal B cell differentiation ( J:199530 )

• in the bone marrow

decreased B cell number ( J:199530 )

• in the bone marrow

increased B cell number ( J:199530 )

• in Peyer's patches

increased germinal center B cell number ( J:199530 )

• in the Peyer's patch and mesenteric lymph nodes before and after immunization with sheep red blood cell

• in peripheral lymph nodes after immunization with sheep red blood cell

abnormal spleen morphology ( J:199530 )

• less distinct light zone and dark zone regions in the spleen of mice immunized with sheep red blood cell

increased spleen germinal center number ( J:199530 )

• in sheep red blood cell immunized mice

increased spleen germinal center size ( J:199530 )

• in sheep red blood cell immunized mice

increased IgA level ( J:199530 )

• in mice immunized with sheep red blood cell

increased IgG1 level ( J:199530 )

• in mice immunized with sheep red blood cell

increased IgG2b level ( J:199530 )

• in mice immunized with TNP-KLH or sheep red blood cell

increased IgG2c level ( J:199530 )

• in mice immunized with TNP-KLH or sheep red blood cell

increased IgG3 level ( J:199530 )

• in mice immunized with TNP-KLH or sheep red blood cell

increased IgM level ( J:199530 )

• slight in mice immunized with TNP-KLH or sheep red blood cell