About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm1Yjc
targeted mutation 1, Y Jeffrey Chiang
MGI:5476675
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp53tm1Yjc/Trp53tm1Yjc B6.129S1-Trp53tm1Yjc MGI:5476679
cn2
Cd19tm1(cre)Cgn/Cd19+
Trp53tm1Yjc/Trp53tm1Yjc
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6 MGI:5476680


Genotype
MGI:5476679
hm1
Allelic
Composition
Trp53tm1Yjc/Trp53tm1Yjc
Genetic
Background
B6.129S1-Trp53tm1Yjc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Yjc mutation (0 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Trp53tm1Yjc/Trp53tm1Yjc mice develop B cell lymphomas

mortality/aging
• all mice die by 48 weeks of age due to lymphoma development

immune system
N
• radiation-induced apoptosis in thymocytes is normal
• in irradiated spleen cells
• in 23 of 29 mice at death
• compression of white pulp in some mice
• marginal zone invasion of red pulp

neoplasm
• with marginal zone invasion of red pulp
• in two mice at death

liver/biliary system
• in one mouse at death

integument
• in two mice at death

cellular
• in irradiated spleen cells

hematopoietic system
• in irradiated spleen cells
• in 23 of 29 mice at death
• compression of white pulp in some mice
• marginal zone invasion of red pulp




Genotype
MGI:5476680
cn2
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Trp53tm1Yjc/Trp53tm1Yjc
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Trp53tm1Yjc mutation (0 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice do not develop B cell lymphomas





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/03/2020
MGI 6.15
The Jackson Laboratory