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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il7rtm1.1Asin
targeted mutation 1.1, Alfred Singer
MGI:5468999
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5469010
cn2
 		Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:5469008
cn3
 		Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469007
cn4
 		Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469009
cn5
 		Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd4-cre)1Cwi/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:5469006


Genotype
MGI:5469010
cn1
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469008
cn2
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (2 available); any Il4ra mutation (41 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469007
cn3
Allelic
Composition		 Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery




Genotype
MGI:5469009
cn4
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (43 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469006
cn5
Allelic
Composition		 Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory