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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Selenoptm3.1Rfb
targeted mutation 3.1, Raymond F Burk
MGI:5466366
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Selenoptm3.1Rfb/Selenoptm3.1Rfb
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA MGI:5466370


Genotype
MGI:5466370
cn1
Allelic
Composition
Selenoptm3.1Rfb/Selenoptm3.1Rfb
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background
involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selenoptm3.1Rfb mutation (2 available); any Selenop mutation (22 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Curling and splaying of hind limbs in Selenoptm3.1Rfb/Selenoptm3.1Rfb Speer6-ps1Tg(Alb-cre)21Mgn/0 mice fed a selenium-deficient diet

reproductive system
• in mice fed a selenium-deficient diet
• kinked spermatozoa in mice fed a selenium-deficient diet

homeostasis/metabolism
• mice fed a selenium-adequate diet supplemented with selenium exhibit increased liver selenium incorporation and decreased whole body, liver, kidney, brain, testis and muscle compared with control mice
• mice fed a selenium-deficient diet exhibit increased liver selenium levels and decreased kidney, brain, testis, muscle and whole body levels compared with control mice
• more than doubled in mice fed a selenium-adequate diet supplemented with selenium

behavior/neurological
• beginning at 16 weeks in mice fed a selenium-deficient diet
• wide-based gait in hind limbs beginning at 22 weeks in mice fed a selenium-deficient diet

growth/size/body
• mice fed a selenium-deficient diet cease to gain weight after 12 weeks unlike control mice

renal/urinary system
• more than doubled in mice fed a selenium-adequate diet supplemented with selenium

cellular
• in mice fed a selenium-deficient diet
• kinked spermatozoa in mice fed a selenium-deficient diet





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory