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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hbb-b1Rbc13
red blood cell mutant 13
MGI:5460881
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hbb-b1Rbc13/Hbb-b1Rbc13 involves: BALB/c * C57BL/6 MGI:5460885
ht2
 		Hbb-b1Rbc13/Hbb-b1+ involves: BALB/c * C57BL/6 MGI:5460886
ht3
 		Hbb-b1Rbc13/Hbb-b1MommeD7 involves: BALB/c * C57BL/6 * FVB/N MGI:5460887
cx4
 		Hbb-b1Rbc13/Hbb-b1tm1Unc
Hbb-b2tm1Unc/Hbb-b2+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5460889


Genotype
MGI:5460885
hm1
Allelic
Composition		 Hbb-b1Rbc13/Hbb-b1Rbc13
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1Rbc13 mutation (1 available); any Hbb-b1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

integument
pallor ( J:190446 )
• progressive pallor starting at E16.5

liver/biliary system
abnormal liver morphology ( J:190446 )
• fetal livers contain poorly hemoglobinized erythroblasts with inclusions
liver hypoplasia ( J:190446 )
• fewer fetal liver cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
beta thalassemia DOID:12241 OMIM:613985
 J:190446




Genotype
MGI:5460886
ht2
Allelic
Composition		 Hbb-b1Rbc13/Hbb-b1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1Rbc13 mutation (1 available); any Hbb-b1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:190446 )
• increased 5-fold in size
abnormal definitive hematopoiesis ( J:190446 )
• occasional basophilic stippling in peripheral blood smears
microcytic anemia ( J:190446 )
• at 7 weeks of age
increased nucleated erythrocyte cell number ( J:190446 )
• increase of immature CD71+ TER-119+ erythroid cells
anisocytosis ( J:190446 )
• marked
leptocytosis ( J:190446 )
• abundant target cells
schistocytosis ( J:190446 )
• mild red cell fragmentation
increased erythrocyte clearance ( J:190446 )
• a 50% reduction in red cell half-life

immune system
enlarged spleen ( J:190446 )
• increased 5-fold in size

growth/size/body
enlarged spleen ( J:190446 )
• increased 5-fold in size




Genotype
MGI:5460887
ht3
Allelic
Composition		 Hbb-b1Rbc13/Hbb-b1MommeD7
Genetic
Background		 involves: BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1MommeD7 mutation (2 available); any Hbb-b1 mutation (7 available)
Hbb-b1Rbc13 mutation (1 available); any Hbb-b1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
pallor ( J:190446 )
• at E16.5 phenotype is similar to mice homozygous for either allele




Genotype
MGI:5460889
cx4
Allelic
Composition		 Hbb-b1Rbc13/Hbb-b1tm1Unc
Hbb-b2tm1Unc/Hbb-b2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbb-b1Rbc13 mutation (1 available); any Hbb-b1 mutation (7 available)
Hbb-b1tm1Unc mutation (2 available); any Hbb-b1 mutation (7 available)
Hbb-b2tm1Unc mutation (2 available); any Hbb-b2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
anemia ( J:190446 )
• severe




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory