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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cx3cr1tm2.1(cre/ERT2)Litt
targeted mutation 2.1, Dan R Littman
MGI:5450813
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gpr35em2Niess/Gpr35em2Niess
Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:6502846
cx2
 		Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
Vps35Gt(RRK261)Byg/Vps35Gt(RRK261)Byg 		involves: 129P2/OlaHsd * C57BL/6 MGI:6450125


Genotype
MGI:6502846
cn1
Allelic
Composition		 Gpr35em2Niess/Gpr35em2Niess
Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm2.1(cre/ERT2)Litt mutation (1 available); any Cx3cr1 mutation (45 available)
Gpr35em2Niess mutation (0 available); any Gpr35 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased colon length ( J:300275 )
• in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced colon reduction
increased susceptibility to induced colitis ( J:300275 )
• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment
• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced colitis

growth/size/body
increased susceptibility to weight loss ( J:300275 )
• in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced weight loss

immune system
increased susceptibility to induced colitis ( J:300275 )
• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment
• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS
• however, treatment with TNF attenuates exacerbated DSS-induced colitis

homeostasis/metabolism
abnormal corticosterone level ( J:300275 )
• lower corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS
• however, treatment with TNF increases corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS




Genotype
MGI:6450125
cx2
Allelic
Composition		 Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
Vps35Gt(RRK261)Byg/Vps35Gt(RRK261)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm2.1(cre/ERT2)Litt mutation (1 available); any Cx3cr1 mutation (45 available)
Vps35Gt(RRK261)Byg mutation (1 available); any Vps35 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased neuron apoptosis ( J:292365 )
• after induced cortical ischemic stroke following tamoxifen-induced knockout
• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

hematopoietic system
increased macrophage cell number ( J:292365 )
• increased number of macrophages in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• normal number of macrophages in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
microgliosis ( J:292365 )
• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

homeostasis/metabolism
increased transforming growth factor beta level ( J:292365 )
• increased expression of TGFB in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
decreased cerebral infarct size ( J:292365 )
• after induced cortical ischemic stroke following tamoxifen-induced knockout

immune system
increased macrophage cell number ( J:292365 )
• increased number of macrophages in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• normal number of macrophages in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
microgliosis ( J:292365 )
• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
decreased interleukin-1 beta secretion ( J:292365 )
• reduced expression of IL1B in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
increased interleukin-10 secretion ( J:292365 )
• increased expression of IL10 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
increased interleukin-4 secretion ( J:292365 )
• increased expression of IL4 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
decreased interleukin-6 secretion ( J:292365 )
• reduced expression of IL6 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
decreased tumor necrosis factor secretion ( J:292365 )
• reduced expression of TNFA in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:292365 )
• decreased cortex infarction size after induced cortical ischemic stroke following tamoxifen-induced knockout
• decreased neuronal cell death after induced cortical ischemic stroke following tamoxifen-induced knockout
• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout
• lower increase of astrocyte number (reduced astrocytosis) in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• reduced number of pro-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

nervous system
decreased neuron apoptosis ( J:292365 )
• after induced cortical ischemic stroke following tamoxifen-induced knockout
• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout
microgliosis ( J:292365 )
• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout
decreased cerebral infarct size ( J:292365 )
• after induced cortical ischemic stroke following tamoxifen-induced knockout




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory