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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec63tm1Som
targeted mutation 1, Stefan Somlo
MGI:5442171
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0 		involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5442324
cn2
 		Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL MGI:5442321
cn3
 		Pkd2tm2Som/Pkd2+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL MGI:5442322
cn4
 		Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J MGI:5442320
cn5
 		Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * ICR MGI:5442319


Genotype
MGI:5442324
cn1
Allelic
Composition		 Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(CAG-cre/Esr1*)1Lbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188763 )
• in mice treated with a high does tamoxifen induction regime

liver/biliary system
liver cyst ( J:188763 )
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype

growth/size/body
liver cyst ( J:188763 )
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype




Genotype
MGI:5442321
cn2
Allelic
Composition		 Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm1Som mutation (0 available); any Pkd1 mutation (153 available)
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased kidney apoptosis ( J:188763 )
• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
increased kidney cell proliferation ( J:188763 )
• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
kidney cyst ( J:188763 )
• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
abnormal loop of Henle ascending limb thick segment morphology ( J:188763 )
• dilated to a lesser extent than collecting tubules

cellular
increased kidney apoptosis ( J:188763 )
• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
increased kidney cell proliferation ( J:188763 )
• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice

homeostasis/metabolism

growth/size/body
kidney cyst ( J:188763 )
• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
increased kidney weight ( J:188763 )




Genotype
MGI:5442322
cn3
Allelic
Composition		 Pkd2tm2Som/Pkd2+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2tm2Som mutation (0 available); any Pkd2 mutation (84 available)
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system

homeostasis/metabolism

growth/size/body
kidney cyst ( J:188763 )




Genotype
MGI:5442320
cn4
Allelic
Composition		 Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Tg(Pkd1)248Som mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:188763 )
• mild at P45

growth/size/body
kidney cyst ( J:188763 )
• mild at P45




Genotype
MGI:5442319
cn5
Allelic
Composition		 Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188763 )
• by P60 associated with kidney cysts

renal/urinary system
kidney cyst ( J:188763 )
• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype
abnormal loop of Henle ascending limb thick segment morphology ( J:188763 )
• dilated to a lesser extent than collecting tubules

homeostasis/metabolism

growth/size/body
kidney cyst ( J:188763 )
• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory