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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc39a4tm2Gka
targeted mutation 2, Glen K Andrews
MGI:5438020
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Slc39a4tm2Gka/Slc39a4tm2Gka
Tg(Vil-cre/ERT2)23Syr/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5438021


Genotype
MGI:5438021
cn1
Allelic
Composition
Slc39a4tm2Gka/Slc39a4tm2Gka
Tg(Vil-cre/ERT2)23Syr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a4tm2Gka mutation (1 available); any Slc39a4 mutation (15 available)
Tg(Vil-cre/ERT2)23Syr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Growth retardation of tamoxifen treated Slc39a4tm2Gka/Slc39a4tm2Gka Tg(Vil-cre/ERT2)23Syr/0 mice

mortality/aging
• mice treated with tamoxifen as neonates die within a week of weaning unless excess zinc is provided in the drinking water
• mice treated with tamoxifen (3 injections) 5 days after weaning die unless provided with excess zinc in the drinking water
• removal of excess zinc in the drinking water results in precipitous weight loss and death in mice treated with tamoxifen as neonates or after weaning
• excess zinc must be provided by day 6 after tamoxifen treatment to prevent lethality
• mice treated with tamoxifen at 7 weeks of age die around 1 week after the treatment

growth/size/body
• rapid weight loss after weaning in mice treated with tamoxifen as neonates unless excess zinc is provided in the drinking water
• rapid weight loss is seen within a few days of tamoxifen treatment in mice treated with tamoxifen (3 injections) 5 days after weaning despite normal food consumption and much of this weight loss involves loss of muscle and bone
• mice given a single injection of tamoxifen after weaning slowly lose weight, about half recover and resume normal growth
• rapid weight loss is also seen when mice are treated with tamoxifen at 7 weeks of age
• mice treated with tamoxifen as neonates provided excess zinc in the drinking water at weaning still fail to gain much body weight following weaning

homeostasis/metabolism
• increase in manganese in the liver by 4 days after tamoxifen treatment with levels about twice normal by 8 days after treatment
• about a 50% decrease in iron levels in the small intestine by 4 days after tamoxifen treatment
• decrease in copper levels in the pancreas by 4 days after tamoxifen treatment
• by 4 days after tamoxifen treatment
• largest loss of copper occurs in the small intestine
• by 4 days after tamoxifen treatment
• by 8 days after tamoxifen treatment
• levels are about twice normal by 8 days after tamoxifen treatment
• decrease in zinc levels in the small intestine, pancreas and liver at 4 days after tamoxifen treatment
• decrease in zinc levels correlates with the beginning of weight loss
• levels in the liver normalize by 8 days after tamoxifen treatment

digestive/alimentary system
• decrease in proliferation at 2, 4 and 6 days after tamoxifen treatment
• progressive and profound disorganization of the crypt architecture after tamoxifen treatment
• crypts become elongated 2 days after tamoxifen treatment
• after tamoxifen treatment Paneth cells contain large cytoplasmic vacuoles and the store of labile zinc is rapidly depleted
• about a 50% decrease in iron levels in the small intestine by 4 days after tamoxifen treatment
• progressive and profound disorganization of the villus after tamoxifen treatment
• by 6 days after tamoxifen treatment epithelial cells have lost much of their columnar morphology becoming cuboidal with centric nuclei
• by 6 days after tamoxifen treatment the lamina propria appears disorganized, occupies more space in the villi, and often contains red blood cells and cells with pyknotic nuclei

liver/biliary system
• increase in manganese in the liver by 4 days after tamoxifen treatment with levels about twice normal by 8 days after treatment
• by 4 days after tamoxifen treatment
• by 8 days after tamoxifen treatment
• levels are about twice normal by 8 days after tamoxifen treatment

muscle
• rapid muscle weight loss is seen within a few days of tamoxifen treatment in mice treated with tamoxifen 5 days after weaning despite normal food consumption

skeleton
• loss of bone mass is seen within a few days of tamoxifen treatment in mice treated with tamoxifen 5 days after weaning despite normal food consumption

cellular
• decrease in proliferation at 2, 4 and 6 days after tamoxifen treatment

endocrine/exocrine glands
• progressive and profound disorganization of the crypt architecture after tamoxifen treatment
• crypts become elongated 2 days after tamoxifen treatment
• after tamoxifen treatment Paneth cells contain large cytoplasmic vacuoles and the store of labile zinc is rapidly depleted

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acrodermatitis enteropathica DOID:0050605 OMIM:201100
J:187178





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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory