Mouse Genome Informatics
tg1
    Tg(SERPINC1-SV40)A1Pbr/Tg(SERPINC1-SV40)A1Pbr
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mutants die at around 5 months of age

tumorigenesis

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:101541


Mouse Genome Informatics
tg2
    Tg(SERPINC1-SV40)A1Pbr/0
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mutants do not survive for more than 10 months and most often die around 8 months of age

tumorigenesis
• lung metastasis is observed in some mutants
• all mice develop hepatocellular carcinoma at 8 months of age
• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma

liver/biliary system
• mutants exhibit anisocaryosis and abnormal mitosis in the liver at 2 months of age
• hepatic cytolysis occurs as early as 3-4 weeks of age and reaches a first peak at 7 weeks, before the formation of nodules, then a second increase in cytolysis is seen between 6-8 months

cellular
• anisocaryosis in the liver at 2 months of age

hematopoietic system
• seen at 2 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:101541