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Allele Symbol Allele Name Allele ID |
Tg(SERPINC1-SV40)A1Pbr transgene insertion A1, Pascale Briand MGI:5437686 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants die at around 5 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:101541 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants do not survive for more than 10 months and most often die around 8 months of age
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• all mice develop hepatocellular carcinoma at 8 months of age
• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma
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• lung metastasis is observed in some mutants
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• mutants exhibit anisocaryosis and abnormal mitosis in the liver at 2 months of age
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• all mice develop hepatocellular carcinoma at 8 months of age
• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma
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• hepatic cytolysis occurs as early as 3-4 weeks of age and reaches a first peak at 7 weeks, before the formation of nodules, then a second increase in cytolysis is seen between 6-8 months
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• anisocaryosis in the liver at 2 months of age
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• seen at 2 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:101541 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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