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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SERPINC1-SV40)A1Pbr
transgene insertion A1, Pascale Briand
MGI:5437686
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SERPINC1-SV40)A1Pbr/Tg(SERPINC1-SV40)A1Pbr involves: C57BL/6 * DBA/2 MGI:5437689
tg2
Tg(SERPINC1-SV40)A1Pbr/0 involves: C57BL/6 * DBA/2 MGI:5437688


Genotype
MGI:5437689
tg1
Allelic
Composition
Tg(SERPINC1-SV40)A1Pbr/Tg(SERPINC1-SV40)A1Pbr
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system

mortality/aging
• mutants die at around 5 months of age

neoplasm

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:101541




Genotype
MGI:5437688
tg2
Allelic
Composition
Tg(SERPINC1-SV40)A1Pbr/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants do not survive for more than 10 months and most often die around 8 months of age

neoplasm
• all mice develop hepatocellular carcinoma at 8 months of age
• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma
• lung metastasis is observed in some mutants

liver/biliary system
• mutants exhibit anisocaryosis and abnormal mitosis in the liver at 2 months of age
• all mice develop hepatocellular carcinoma at 8 months of age
• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma
• hepatic cytolysis occurs as early as 3-4 weeks of age and reaches a first peak at 7 weeks, before the formation of nodules, then a second increase in cytolysis is seen between 6-8 months

cellular
• anisocaryosis in the liver at 2 months of age

hematopoietic system
• seen at 2 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:101541





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory