• mutants die at around 5 months of age

• mutants do not survive for more than 10 months and most often die around 8 months of age

• lung metastasis is observed in some mutants

• all mice develop hepatocellular carcinoma at 8 months of age

• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma

• mutants exhibit anisocaryosis and abnormal mitosis in the liver at 2 months of age

• hepatic cytolysis occurs as early as 3-4 weeks of age and reaches a first peak at 7 weeks, before the formation of nodules, then a second increase in cytolysis is seen between 6-8 months

• anisocaryosis in the liver at 2 months of age

• seen at 2 months of age