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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(HLA-DR2)#Lfug
transgene insertion, Lars Fugger
MGI:5429698
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0 		involves: C57BL/6 * DBA/2 MGI:5429703
cx2
 		Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0 		involves: C57BL/6 * DBA/2 MGI:5429705
cx3
 		Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0 		involves: C57BL/6 * DBA/2 * SJL MGI:5429704


Genotype
MGI:5429703
cx1
Allelic
Composition		 Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:134764 )
• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:134764 )
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease
• onset, clinical manifestations and course of disease are highly variable
• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack
CNS inflammation ( J:134764 )
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:134764 )
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects
lethargy ( J:134764 )
• drowsy
abnormal gait ( J:134764 )
• staggering gait
hindlimb paralysis ( J:134764 )
• develops spontaneously in a few (4%) mice

nervous system
CNS inflammation ( J:134764 )
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
 J:134764




Genotype
MGI:5429705
cx2
Allelic
Composition		 Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1.1Cgn mutation (4 available); any Rag2 mutation (117 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:134764 )
• clinical manifestations included both classical and non-classical EAE symptoms
CNS inflammation ( J:134764 )
• focal inflammatory lesions are seen throughout the central nervous system
• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes

behavior/neurological
hindlimb paralysis ( J:134764 )
• seen in all mice with an age of onset ranging from 48 to 102 days

nervous system
CNS inflammation ( J:134764 )
• focal inflammatory lesions are seen throughout the central nervous system
• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes
demyelination ( J:134764 )
• focal demyelinated tissue lesions are seen throughout the central nervous system, including the optic and vestibular nerves

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
 J:134764




Genotype
MGI:5429704
cx3
Allelic
Composition		 Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-CD4)2362Litt mutation (3 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:134764 )
• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:134764 )
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease
• onset, clinical manifestations and course of disease are highly variable
• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack
CNS inflammation ( J:134764 )
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:134764 )
• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects
lethargy ( J:134764 )
• drowsy
abnormal gait ( J:134764 )
• staggering gait

nervous system
CNS inflammation ( J:134764 )
• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
 J:134764




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory