Mouse Genome Informatics
cx1
    Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*)#Rgab/0

involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice are euthanized when they are too paralyzed to reach food and water

behavior/neurological
• in very few mice
• asymmetric hindlimb weakness at 5 to 6 months that progresses to paraplegia
• asymmetric hindlimb weakness at 5 to 6 months that progresses to paraplegia
• myoclonic jerks in some mice

limbs/digits/tail
• plastic tail in very few mice

muscle
• myoclonic jerks in some mice
• in the lower body

nervous system
• myoclonic jerks in some mice
• at 3 months and more prominent at 8 months
• at 3 months and more prominent at 8 months

skeleton

Mouse Models of Human Disease
OMIM IDRef(s)
Creutzfeldt-Jakob Disease; CJD 123400 J:183170


Mouse Genome Informatics
tg2
    Tg(Prnp*)#Rgab/0
involves: C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice are euthanized when they are too paralyzed to reach food and water

behavior/neurological
• in very few mice
• asymmetric hindlimb weakness at 5 to 6 months that progresses to paraplegia
• asymmetric hindlimb weakness at 5 to 6 months that progresses to paraplegia
• myoclonic jerks in some mice

limbs/digits/tail
• plastic tail in very few mice

muscle
• myoclonic jerks in some mice
• in the lower body

nervous system
• myoclonic jerks in some mice
• at 3 months and more prominent at 8 months
• at 3 months and more prominent at 8 months

skeleton

Mouse Models of Human Disease
OMIM IDRef(s)
Creutzfeldt-Jakob Disease; CJD 123400 J:183170