Phenotypes associated with this allele

• Allele Symbol: Pmch^{tm1.1(HBEGF)Rpa}
• Allele Name: targeted mutation 1.1, Richard D Palmiter
• Allele ID: MGI:5319632
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lep^ob/Lep^ob Pmch^tm1.1(HBEGF)Rpa/Pmch^+	B6.Cg-Lep^ob Pmch^tm1.1(DTR)Rpa	MGI:5319635

Genotype
MGI:5319635

cx1

• Allelic Composition: Lep^ob/Lep^ob; Pmch^{tm1.1(HBEGF)Rpa}/Pmch⁺
• Genetic Background: B6.Cg-Lep^ob Pmch^{tm1.1(DTR)Rpa}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuron number ( J:181947 )

• loss of melanin-concentrating hormone expressing neurons following treatment with diptheria toxin

growth/size/body

decreased body weight ( J:181947 )

• modestly decreased in older moderately obese (35-40g) adults following treatment with diptheria toxin compared to similarly treated controls

abnormal postnatal growth ( J:181947 )

• slight reduction in weight gain in young adult males following treatment with diptheria toxin

homeostasis/metabolism

improved glucose tolerance ( J:181947 )

• in older moderately obese adults following treatment with diptheria toxin compared to similarly treated controls

behavior/neurological

behavior/neurological phenotype ( J:181947 )

N • diptheria toxin treatment does not alter food intake

reproductive system

female infertility ( J:181947 )

♀ • in both diptheria toxin and saline treated mice

reduced male fertility ( J:181947 )

♂ • in both diptheria toxin and saline treated mice