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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Drd2tm1.1Mrub
targeted mutation 1.1, Marcelo Rubinstein
MGI:5292350
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn MGI:5292386
cn2
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Tg(Prl-cre)1Mrub/?
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5471747
cn3
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Tg(Nes-cre)1Kln/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5471750


Genotype
MGI:5292386
cn1
Allelic
Composition
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic
Background
B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1.1Mrub mutation (1 available); any Drd2 mutation (58 available)
Slc6a3tm1.1(cre)Bkmn mutation (1 available); any Slc6a3 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• locomotor activity is increased 1.4-fold at low doses in cocaine-treated mice unlike in similarly treated control mice
• at higher doses, cocaine-induced hyperactivity is 3.8-fold compared to 2.8-fold in similarly treated control mice
• mice exhibit increased motivation to work for food compared with control mice
• however, mice exhibit normal profile of loss of responding following cessation of reward delivery
• in an open field that is insensitive to quinpirole treatment
• however, habituation is normal
• locomotor activity is increased 1.4-fold at low doses in cocaine-treated mice unlike in similarly treated control mice
• at higher doses, cocaine-induced hyperactivity is 3.8-fold compared to 2.8-fold in similarly treated control mice

nervous system
• quinpirole fails to induce a slow hyperpolarizing current in dopaminergic neurons unlike in similarly treated control cells
• however, response to baclofen is normal
• decreased and insensitive to sulpiride
• during train stimulation, mice exhibit supramaximal dopamine release that increases during stimulation that is insensitive to sulpiride unlike in control mice

homeostasis/metabolism
• quinpirole fails to induce a slow hyperpolarizing current in dopaminergic neurons or reduce locomotor activity unlike in similarly treated control mice
• sulpiride fails to decreased inhibitory postsynaptic currents unlike in control cells
• tyrosine hydroxylase activity is insensitive to quinpirole unlike in control cells
• however, response to baclofen is normal
• mice treated with haloperidol exhibit greater decrease in locomotion compared with similarly treated control mice




Genotype
MGI:5471747
cn2
Allelic
Composition
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Tg(Prl-cre)1Mrub/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1.1Mrub mutation (1 available); any Drd2 mutation (58 available)
Tg(Prl-cre)1Mrub mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• body weight and body size are normal in males

homeostasis/metabolism
• hyperprolactinemia in both sexes but particularly in females
• haloperidol fails to increase serum prolactin in either sex as it does in controls
• haloperidol induces catatonia as in controls




Genotype
MGI:5471750
cn3
Allelic
Composition
Drd2tm1.1Mrub/Drd2tm1.1Mrub
Tg(Nes-cre)1Kln/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1.1Mrub mutation (1 available); any Drd2 mutation (58 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• reduced body weight and body length in males
• body length at weaning is reduced 10.2% in males
• body weight of males is 14.2% lower than controls at 2 months and 21.7% lower at 6 months

homeostasis/metabolism
N
• prolactin levels are normal
• growth hormone releasing hormone (GHRH) levels are reduced 30%
• 63.2% reduction in growth hormone in the pituitary
• 45.6% reduction in MUP levels
• male MUP levels are similar to female control levels
• haloperidol fails to induce catatonia

behavior/neurological
N
• food intake is normal
• in social dominance tests control C57BL/6 males respond to mutant male mice as if they were females - no social dominance
• resident male C57BL/6 confronted with castrated males swabbed with urine from mutant mice showed reduced aggression
• reduced scent marking of C57NL/6 male mice when placed in cages previously occupied by mutant mice

endocrine/exocrine glands
• 28.1% reduction in the number of growth hormone containing cells in the pituitary

renal/urinary system
• 45.6% reduction in MUP levels
• male MUP levels are similar to female control levels

nervous system
• 28.1% reduction in the number of growth hormone containing cells in the pituitary





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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory