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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G127X)716Mrkl
transgene insertion 716, Stefan L Marklund
MGI:5286585
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SOD1*G127X)716Mrkl/Tg(SOD1*G127X)716Mrkl B6JBom.Cg-Tg(SOD1*G127X)716Mrkl MGI:5286592
tg2
Tg(SOD1*G127X)716Mrkl/0 B6JBom.Cg-Tg(SOD1*G127X)716Mrkl MGI:5286591


Genotype
MGI:5286592
tg1
Allelic
Composition
Tg(SOD1*G127X)716Mrkl/Tg(SOD1*G127X)716Mrkl
Genetic
Background
B6JBom.Cg-Tg(SOD1*G127X)716Mrkl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 250 days

behavior/neurological
• disease progression takes about 7-10 days from the time of first sign compared to about 3 weeks in mice carrying Tg(SOD1*G93A)1Gur
• about 1/3 show forelimb onset rather than hindlimb onset of paralysis

nervous system
• develop Lewy body like hyaline inclusions in astrocytes
• develop Lewy body like hyaline inclusions in motor neurons

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:175594




Genotype
MGI:5286591
tg2
Allelic
Composition
Tg(SOD1*G127X)716Mrkl/0
Genetic
Background
B6JBom.Cg-Tg(SOD1*G127X)716Mrkl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 477 days





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory