All Phenotypes Pax7<tm1(cre/ERT2)Gaka> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax7^{tm1(cre/ERT2)Gaka}
targeted mutation 1, Gabrielle Kardon
MGI:5141477

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5141594
cn2	Prmt7^tm1.1Rchd/Prmt7^tm1.1Rchd Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NCrl	MGI:6314346
cn3	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos Pax7^{tm1(cre/ERT2)Gaka}/Pax7^{tm1(cre/ERT2)Gaka} Paxbp1^tm1.1Nju/Paxbp1^tm1.1Nju	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr	MGI:6827448
cn4	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5495319
cn5	Six1^tm2.1Mair/Six1^tm2.1Mair Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6Cr * C57BL/6NTac	MGI:5449865
cn6	Zfp422^em1Mode/Zfp422^em1Mode Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	MGI:6477293
cn7	Pax7^{tm1(cre/ERT2)Gaka}/0 Snhg15^tm1.1Nju/Snhg15^tm1.1Nju	involves: C57BL/6J * SJL/J	MGI:6478905
cx8	Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj}/Gt(ROSA)26Sor⁺ Pax7^{tm1(cre/ERT2)Gaka}/?	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl	MGI:6120566

Allelic Composition	Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased satellite cell number ( J:174914 )

• 83-84% of satellite cells are ablated in the right tibialis anterior muscle after 5 doses of tamoxifen and 5days after muscle damage induced by BaCl2 injection

skeletal muscle fibrosis ( J:174914 )

• reduced fibroblast expansion by 52% 5 days after muscle injury in tamoxifen treated mice

impaired skeletal muscle regeneration ( J:174914 )

• 89% reduction in regenerating myofibers 5 days after muscle injury in tamoxifen treated mice

• muscle regeneration dramatically impaired 28 days after injury

• right tibialis anterior muscle entirely fibrotic at 28 days and uninjured left tibialis anterior is reduced by 38%

• similar result when damage induced with cardiotoxin, no recovery after 56 days

Allelic Composition	Prmt7^tm1.1Rchd/Prmt7^tm1.1Rchd Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)
Prmt7^tm1.1Rchd mutation (0 available); any Prmt7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle physiology ( J:271361 )

• satellite cells isolated from 8 month tamoxifen-treated mice exhibit premature senescence unlike control cells

impaired skeletal muscle regeneration ( J:271361 )

• tamoxifen-treated mice subjected to cardiotoxin-induced muscle injury exhibit smaller and poorly organized regenerating myofibers compared with control mice

cellular

early cellular replicative senescence ( J:271361 )

• satellite cells or cardiotoxin-injured tibialis anterior muscles isolated from 8 month tamoxifen-treated mice exhibit premature senescence unlike control cells

homeostasis/metabolism

abnormal response to injury ( J:271361 )

• cardiotoxin-injured tibialis anterior muscles isolated from 8 month tamoxifen-treated mice exhibit premature senescence unlike control cells

Allelic Composition	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos Pax7^{tm1(cre/ERT2)Gaka}/Pax7^{tm1(cre/ERT2)Gaka} Paxbp1^tm1.1Nju/Paxbp1^tm1.1Nju
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (942 available)
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)
Paxbp1^tm1.1Nju mutation (0 available); any Paxbp1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial morphology ( J:304562 )

• fragmented mitochondria, largely restricted to perinuclear region, lacking interconnecting tubular network in activated muscle stem cells

abnormal respiratory electron transport chain ( J:304562 )

• defective cellular respiration and glycolysis

abnormal mitochondrial ATP synthesis coupled electron transport ( J:304562 )

• defective cellular respiration and glycolysis

decreased mitochondrial fission ( J:304562 )

• defective mitochondrial biogenesis in activated muscle stem cells

abnormal oxidative phosphorylation ( J:304562 )

• defective cellular respiration and glycolysis

muscle

impaired skeletal muscle regeneration ( J:304562 )

• virtual absence of regenerating myofibers 5 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles and no muscle regeneration after 14 nor 30 days

• adipocyte infiltration 30 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

myopathy ( J:194308 )

• when tamoxifen is administered after 3 weeks of age myopathy develops by 12 months

neoplasm

neoplasm ( J:194308 )

N	• no abnormal tumor development when treated with tamoxifen after 3 weeks of age

Allelic Composition	Six1^tm2.1Mair/Six1^tm2.1Mair Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6Cr * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)
Six1^tm2.1Mair mutation (0 available); any Six1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Perturbed myogenic differentiation of Six1^tm2.1Mair/Six1^tm2.1Mair Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺ satellite cell descendants ex vivo

muscle

muscle phenotype ( J:190460 )

N	• normal muscle tissue weights or histology up to a year after tamoxifen treatment

skeletal muscle fibrosis ( J:190460 )

• in tamoxifen-treated mice subjected to a single cardiotoxin injury

abnormal muscle physiology ( J:190460 )

• satellite cells from tamoxifen-treated mice exhibit reduced ability to differentiate of satellite cell descendants ex vivo and increased self-renewal capacity in vivo compared with control cells

• ex vivo satellite cells from tamoxifen-treated mice exhibit increased self-renewal compared with control cells

• however, satellite cells exhibit normal quiescence, activation and proliferation and polarity of division

abnormal muscle regeneration ( J:190460 )

• satellite cells from tamoxifen-treated mice form smaller myotubes containing fewer nuclei ex vivo compared with control cells

• regenerating muscle from tamoxifen-treated mice subjected to a single cardiotoxin injury exhibit smaller newly formed myofibers with fewer nuclei, numerous lagged fibers of small caliber, reduced cell size and necrotic myofibers compared with controls

Allelic Composition	Zfp422^em1Mode/Zfp422^em1Mode Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)
Zfp422^em1Mode mutation (0 available); any Zfp422 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myoblast differentiation ( J:297035 )

• decrease in the number of myogenin positive cells in cultured satellite cells from tamoxifen treated mice indicating a defect in myoblast differentiation

• when induced to differentiate for 3 days satellite cells for fewer myotubes and have reduced fusion and differentiation indices

impaired skeletal muscle regeneration ( J:297035 )

• following CTX-induced muscle injury muscles in tamoxifen treated mice show smaller regenerated myofiber cross-section area

cellular

abnormal myoblast differentiation ( J:297035 )

• decrease in the number of myogenin positive cells in cultured satellite cells from tamoxifen treated mice indicating a defect in myoblast differentiation

• when induced to differentiate for 3 days satellite cells for fewer myotubes and have reduced fusion and differentiation indices

Allelic Composition	Pax7^{tm1(cre/ERT2)Gaka}/0 Snhg15^tm1.1Nju/Snhg15^tm1.1Nju
Genetic Background	involves: C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)
Snhg15^tm1.1Nju mutation (0 available); any Snhg15 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

delayed skeletal muscle regeneration ( J:291983 )

• delayed muscle regeneration after knockout induction by tamoxifen injection and BaCl₂ injection into tibialis anterior (TA) muscles at age 2 months: reduced number of embryonic myosin heavy chain expressing myofibers 4 days after BaCl₂ injection

• reduced myoblast proliferation after BaCl₂ injection

• reduced in vitro proliferation of stem cells after BaCl₂ injection

Allelic Composition	Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj}/Gt(ROSA)26Sor⁺ Pax7^{tm1(cre/ERT2)Gaka}/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:256652 )

• mice are viable and healthy in the absence of tamoxifen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23