Phenotypes associated with this allele

• Allele Symbol: Gbp2b^tm1Tigm
• Allele Name: targeted mutation 1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5013366
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gbp2b^tm1Tigm/Gbp2b^tm1Tigm	B6.129S5-Gbp2b^tm1Tigm/Jdmm	MGI:5013370

Genotype
MGI:5013370

hm1

• Allelic Composition: Gbp2b^tm1Tigm/Gbp2b^tm1Tigm
• Genetic Background: B6.129S5-Gbp2b^tm1Tigm/Jdmm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:172364 )

• in mice infected with Mycobacterium bovis BCG

immune system

immune system phenotype ( J:172364 )

N • mice exhibit normal B, CD4+ and CD8+ T, and CD11b+ phagocytic cell numbers

abnormal macrophage physiology ( J:172364 )

• macrophage exhibit impaired killing compared with wild-type cells

increased susceptibility to bacterial infection ( J:172364 )

• mice infected with Listeria monocytogenes exhibit increased bacterial load in the spleen and liver, weight loss, and sporadic diarrhea compared with similarly treated wild-type mice

• mice infected with Mycobacterium bovis BCG exhibit increased mycobacterial load in the lungs and become moribund by 10 to 14 weeks after infection compared with wild-type mice

• however, infected mice exhibit normal granuloma formation and IFN-gamma response

increased susceptibility to bacterial infection induced morbidity/mortality ( J:172364 )

• in mice infected with Mycobacterium bovis BCG

growth/size/body

weight loss ( J:172364 )

• in mice infected with Listeria monocytogenes

digestive/alimentary system

diarrhea ( J:172364 )

• sporadic in mice infected with Listeria monocytogenes

hematopoietic system

abnormal macrophage physiology ( J:172364 )

• macrophage exhibit impaired killing compared with wild-type cells