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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl
targeted mutation 1, Merck Research Laboratory
MGI:5007772
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+ Not Specified MGI:5008583
cn2
 		Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Ptentm1Hwu/Ptentm1Hwu 		involves: 129S4/SvJae * C57BL/6 MGI:5008587
cn3
 		Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5008586
cx4
 		Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1.1Hwu/Pten+ 		involves: 129S4/SvJae * C57BL/6NTac MGI:5008591


Genotype
MGI:5008583
ht1
Allelic
Composition		 Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal glucose homeostasis ( J:170965 )
• doxycycline-treated mice exhibit impaired glucose clearance during intraperitoneal glucose tolerance test compared with wild-type mice
hyperglycemia ( J:170965 )
• in doxycycline-treated mice
• however, withdrawal of doxycycline restores glucose levels
increased circulating insulin level ( J:170965 )
• in doxycycline-treated mice




Genotype
MGI:5008587
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:170965 )
• tamoxifen-treated mice survive 57 days unlike control mice

immune system
enlarged spleen ( J:170965 )
• in tamoxifen-treated mice
increased spleen weight ( J:170965 )
• in tamoxifen-treated mice
increased memory B cell number ( J:170965 )
• in tamoxifen-treated mice
decreased B cell number ( J:170965 )
• in tamoxifen-treated mice
enlarged lymph nodes ( J:170965 )
• in tamoxifen-treated mice

neoplasm
increased acute lymphoblastic leukemia incidence ( J:170965 )
• tamoxifen-treated mice develop T cell acute lymphoblastic leukemia unlike control mice

behavior/neurological
hunched posture ( J:170965 )
• in tamoxifen-treated mice

growth/size/body
weight loss ( J:170965 )
• in tamoxifen-treated mice
enlarged spleen ( J:170965 )
• in tamoxifen-treated mice
increased spleen weight ( J:170965 )
• in tamoxifen-treated mice

integument
disheveled coat ( J:170965 )
• scruffy coat in tamoxifen-treated mice

hematopoietic system
enlarged spleen ( J:170965 )
• in tamoxifen-treated mice
increased spleen weight ( J:170965 )
• in tamoxifen-treated mice
increased memory B cell number ( J:170965 )
• in tamoxifen-treated mice
decreased B cell number ( J:170965 )
• in tamoxifen-treated mice




Genotype
MGI:5008586
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
enlarged prostate gland anterior lobe ( J:170965 )
• in doxycycline-treated mice
increased prostate gland weight ( J:170965 )
• in doxycycline-treated mice
prostate gland hyperplasia ( J:170965 )
• in doxycycline-treated mice
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes
abnormal prostate gland physiology ( J:170965 )
• doxycycline-treated mice exhibit increased proliferation in the prostate gland compared to in Pdk1tm1Dral homozygotes

neoplasm
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes

endocrine/exocrine glands
enlarged prostate gland anterior lobe ( J:170965 )
• in doxycycline-treated mice
increased prostate gland weight ( J:170965 )
• in doxycycline-treated mice
prostate gland hyperplasia ( J:170965 )
• in doxycycline-treated mice
increased prostate gland tumor incidence ( J:170965 )
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes
abnormal prostate gland physiology ( J:170965 )
• doxycycline-treated mice exhibit increased proliferation in the prostate gland compared to in Pdk1tm1Dral homozygotes




Genotype
MGI:5008591
cx4
Allelic
Composition		 Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1.1Hwu/Pten+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Ptentm1.1Hwu mutation (0 available); any Pten mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased thyroid adenoma incidence ( J:170965 )
• in doxycycline-treated mice
increased lymphoma incidence ( J:170965 )
• at 6 to 7 months of age in doxycycline-treated mice

endocrine/exocrine glands
increased thyroid adenoma incidence ( J:170965 )
• in doxycycline-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory