Mouse Genome Informatics
cx1
    Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP)12Vle/0

involves: C3H/HeJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
• 6 months following Dox removal
• 20% loss of dentate gyrus neurons at 1 month and about 75% loss by 3 months after Dox removal
• astrocytic activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
• mutants switched to a doxycycline (Dox)-free diet at 28 days of age show progressive neurodegeneration, with neuron loss in the hippocampal dentate gyrus and neocortex beginning at about 1 month after Dox removal

behavior/neurological
• variable clasping behavior is seen approximately 1-3 months after Dox removal

hematopoietic system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal

immune system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal