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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-TARDBP)12Vle
transgene insertion 12, Virginia M Y Lee
MGI:5000260
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP)12Vle/0
involves: C3H/HeJ * C57BL/6J MGI:5448852
cx2
Tg(NEFH-tTA)8Vle/0
Tg(tetO-TARDBP)12Vle/0
involves: C3H/HeJ * C57BL/6J MGI:5695548


Genotype
MGI:5448852
cx1
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP)12Vle/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (7 available)
Tg(tetO-TARDBP)12Vle mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
• 6 months following Dox removal
• 20% loss of dentate gyrus neurons at 1 month and about 75% loss by 3 months after Dox removal
• astrocytic activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
• mutants switched to a doxycycline (Dox)-free diet at 28 days of age show progressive neurodegeneration, with neuron loss in the hippocampal dentate gyrus and neocortex beginning at about 1 month after Dox removal

behavior/neurological
• variable clasping behavior is seen approximately 1-3 months after Dox removal

hematopoietic system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal

immune system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal




Genotype
MGI:5695548
cx2
Allelic
Composition
Tg(NEFH-tTA)8Vle/0
Tg(tetO-TARDBP)12Vle/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NEFH-tTA)8Vle mutation (3 available)
Tg(tetO-TARDBP)12Vle mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in rare instances, small intranuclear phosphorylated TARDBP+ inclusions are detected in motor cortex or striatum, but not spinal cord
• however, TARDBP+ cytoplasmic inclusions are not detected in brain or spinal cord





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory