nervous system
microgliosis
(
J:170756
)
|
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
|
|
• 6 months following Dox removal
|
|
• 20% loss of dentate gyrus neurons at 1 month and about 75% loss by 3 months after Dox removal
|
astrocytosis
(
J:170756
)
|
• astrocytic activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
|
|
• mutants switched to a doxycycline (Dox)-free diet at 28 days of age show progressive neurodegeneration, with neuron loss in the hippocampal dentate gyrus and neocortex beginning at about 1 month after Dox removal
|
behavior/neurological
|
• variable clasping behavior is seen approximately 1-3 months after Dox removal
|
hematopoietic system
microgliosis
(
J:170756
)
|
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
|
immune system
microgliosis
(
J:170756
)
|
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Amyotrophic Lateral Sclerosis 10, with or without Frontotemporal Dementia; | 612069 | J:170756 | |