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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(IVL-cre/ERT2)1Blpn
transgene insertion 1, Cedric Blanpain
MGI:4999984
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Krastm4Tyj/Kras+
Tg(IVL-cre/ERT2)1Blpn/0
involves: 129S4/SvJae * C57BL/6 MGI:5298090


Genotype
MGI:5298090
cn1
Allelic
Composition
Krastm4Tyj/Kras+
Tg(IVL-cre/ERT2)1Blpn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (55 available)
Tg(IVL-cre/ERT2)1Blpn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 2-4 months following tamoxifen treatment, tumors develop in the face in 40% of treated mutants
• 100% of animals develop lip tumors 2-4 months after tamoxifen treatment
• 2-4 months following RU486 treatment, tumors develop in the back skin in 80% of treated mice
• tumors have hallmarks of benign papillomas with signs of squamous differentiation
• no animals develop invasive carcinoma within 4 months of tamoxifen treatment

craniofacial
• 2-4 months following tamoxifen treatment, tumors develop in the face in 40% of treated mutants
• 100% of animals develop lip tumors 2-4 months after tamoxifen treatment

integument
• hyperplasia of the interfollicular epidermis in TAM treated mice
• after tamoxifen treatment, hyperthickening of the interfollicular epidermis (IFE) is observed, indicating that hyperproliferation of IFE cells and hyperplasia of the IFE results from Kras LSL-G12D activation
• 2-4 months following RU486 treatment, tumors develop in the back skin in 80% of treated mice
• tumors have hallmarks of benign papillomas with signs of squamous differentiation
• no animals develop invasive carcinoma within 4 months of tamoxifen treatment

growth/size/body
• 2-4 months following tamoxifen treatment, tumors develop in the face in 40% of treated mutants
• 100% of animals develop lip tumors 2-4 months after tamoxifen treatment





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory