Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Dsr mutation
(0 available);
any
Hand2 mutation
(12 available)
Hand2tm2.1Dsr mutation
(0 available);
any
Hand2 mutation
(12 available)
Tg(Mef2c-cre)#Blk mutation
(0 available)
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mortality/aging
cardiovascular system
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• immature truncus arteriosis
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• mice lack the anlage of the tricuspid valve between the right atrium and ventricle unlike wild-type mice
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• at E9.5 but not as severely as in Hand2tm1Dsr homozygotes
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muscle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1Krc mutation
(0 available);
any
Nkx2-5 mutation
(21 available)
Tg(Mef2c-cre)#Blk mutation
(0 available)
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mortality/aging
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• early embryonic lethality at E10-E10.5
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cardiovascular system
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• foreshortened outflow tract
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• loss of right ventricle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef25tm1.1Xya mutation
(0 available);
any
Arhgef25 mutation
(35 available)
Tg(Mef2c-cre)#Blk mutation
(0 available)
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mortality/aging
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N |
• mice are born in the expected Mendelian ratio
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cardiovascular system
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N |
• mice exhibit normal development of the second heart field
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3Hui mutation
(0 available);
any
Irx3 mutation
(24 available)
Irx5tm3Hui mutation
(0 available);
any
Irx5 mutation
(30 available)
Tg(Mef2c-cre)#Blk mutation
(0 available)
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cardiovascular system
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• recapitulates outflow tract abnormalities seen in germ line double null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mef2c-cre)#Blk mutation
(0 available)
Zic3tm1.1Smwa mutation
(0 available);
any
Zic3 mutation
(37 available)
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normal phenotype
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• viable with no cardiac looping defects detected
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Analysis Tools