All Phenotypes Vti1a<tm1Gfvm> MGI Mouse

• at E18.5, mice exhibit an unusual bundle of fibers, consisting of corticostriatal and thamacocortical axons, on the lateral side of the striatum unlike in wild-type mice

abnormal innervation ( J:169107 )

• superior cervical ganglia fail to innervate the mandibular gland unlike in wild-type mice

abnormal nervous system development ( J:169107 )

abnormal axon extension ( J:169107 )

• dorsal root ganglia explants exposed to NGF exhibit fewer and shorter neurites compared with similarly treated wild-type explants

abnormal axon guidance ( J:169107 )

• at E14.5, thalamocortical axons do not cross the pallio-subpallial border unlike in wild-type mice

• at E18.5, thalamocortical axons fail to reach the cortex and remain within the internal capsule region unlike in wild-type mice

• numerous fiber tracts in the central nervous system are missing, reduced in size, or misrouted compared to in wild-type mice

abnormal cranial ganglia morphology ( J:169107 )

small petrosal ganglion ( J:169107 )

• at E14.5

vestibular ganglion hypoplasia ( J:169107 )

• mild at E14.5

vestibular ganglion degeneration ( J:169107 )

• mild

decreased optic chiasm size ( J:169107 )

• diminished

abnormal sensory ganglion morphology ( J:169107 )

small geniculate ganglion ( J:169107 )

small trigeminal ganglion ( J:169107 )

• beginning at E12.5 and worsening with age

small nodose ganglion ( J:169107 )

• at E14.5

dorsal root ganglion degeneration ( J:169107 )

• at E14.5 and worsening with age

neurodegeneration ( J:169107 )

• progressive in the peripheral nervous system (severe in the trigeminal, nodose, petrosal, geniculate, and dorsal root ganglia; moderate in the superior cervical ganglia; mild in the vestibular and cochlear ganglia)

cellular phenotype ( J:169107 )

N	• cells exhibit normal plasma membrane, early and late endosomes, and lysosomes

increased neuron apoptosis ( J:169107 )

• in the trigeminal ganglia