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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tle5tm1.1Mmt
targeted mutation 1.1, Makoto M Taketo
MGI:4888012
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tle5tm1.1Mmt/Tle5tm1.1Mmt
Apctm1Mmt/Apc+
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129S2/SvPas * C57BL/6 * DBA * SJL MGI:4888016


Genotype
MGI:4888016
cn1
Allelic
Composition		 Tle5tm1.1Mmt/Tle5tm1.1Mmt
Apctm1Mmt/Apc+
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Mmt mutation (0 available); any Apc mutation (154 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Tle5tm1.1Mmt mutation (0 available); any Tle5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon adenocarcinoma incidence ( J:168065 )
• adenocarcinomas by histopathological definition
• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apctm1Mmt adenomas, without a very malignant appearance
increased small intestine adenocarcinoma incidence ( J:168065 )
• adenocarcinomas by histopathological definition
• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apctm1Mmt adenomas, without a very malignant appearance
increased metastatic potential ( J:168065 )
• treated with 4-hydroxytamoxifen to activate Cre recombinase at 3 weeks of age
• tumor invasion and intravasation into the smooth muscle layer of the small intestine and colon at 17 weeks of age
• in polyps larger than 2 mm in diameter, about half of them is found invading into the submucosa or beyond
• often seen inside vessels that are distended, reminiscent of tumor embolism

digestive/alimentary system
increased colon adenocarcinoma incidence ( J:168065 )
• adenocarcinomas by histopathological definition
• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apctm1Mmt adenomas, without a very malignant appearance
increased small intestine adenocarcinoma incidence ( J:168065 )
• adenocarcinomas by histopathological definition
• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apctm1Mmt adenomas, without a very malignant appearance




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory