Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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skeleton
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• nearly all aspects of the Tg(Col1a1-Runx2)#Pmt phenotype are reversed
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• osteocyte numbers in the cortical bone are reduced compared to in wild-type mice but not as severely as in Tg(Col1a1-Runx2)#Pmt mice
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• mice exhibit reduced cortical mineral apposition rates compared with wild-type mice
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• fracture rate is increased compared to in wild-type mice but not as severely as in Tg(Col1a1-Runx2)#Pmt mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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skeleton
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• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice
• however, mineralization occurs unlike in Runx2tm1Mjo heterozygotes
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• clavicle is smaller than in wild-type mice but not as severely reduced as in Runx2tm1Mjo heterozygotes
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• mice exhibit an increase in bone volume compared with wild-type mice
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• mice exhibit an increase in bone volume and trabeculae number and a decrease in trabecular space compared with wild-type mice
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• mice exhibit an increase in bone mass compared with wild-type mice
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• mice exhibit increased bone formation compared to in wild-type mice
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craniofacial
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• the mineralized midpoint of the hyoid bone is decreased in length compared to in wild-type mice
• however, mineralization occurs unlike in Runx2tm1Mjo heterozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2tm1Mjo mutation
(0 available);
any
Runx2 mutation
(42 available)
Tg(Eno2tTA)#Nes mutation
(0 available)
Tg(tetO-Zfp521)#Rbar mutation
(0 available)
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skeleton
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• at P25, mice exhibit a defined nonmineralization area between the anterior and posterior fontanelles compared to in wild-type mice that is larger than in Runx2tm1Mjo heterozygotes
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• the midportion of the hyoid bone fails to mineralize unlike in wild-type mice
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• to a greater extent than in Runx2tm1Mjo heterozygotes
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craniofacial
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• at P25, mice exhibit a defined nonmineralization area between the anterior and posterior fontanelles compared to in wild-type mice that is larger than in Runx2tm1Mjo heterozygotes
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• the midportion of the hyoid bone fails to mineralize unlike in wild-type mice
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Analysis Tools