About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Slc32a1-cre)2.1Hzo
transgene insertion 2.1, Huda Y Zoghbi
MGI:4867735
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(Slc32a1-cre)2.1Hzo/0
involves: 129 * C57BL/6J * FVB MGI:6194750
cn2
Mecp2tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N MGI:4999647


Genotype
MGI:6194750
cn1
Allelic
Composition
Celf4tm1.1Frk/Celf4tm1.1Frk
Tg(Slc32a1-cre)2.1Hzo/0
Genetic
Background
involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4tm1.1Frk mutation (2 available); any Celf4 mutation (18 available)
Tg(Slc32a1-cre)2.1Hzo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seizure threshold measured by ECT test in this conditional null shows a decrease in both males and females

nervous system
• seizure threshold measured by ECT test in this conditional null shows a decrease in both males and females




Genotype
MGI:4999647
cn2
Allelic
Composition
Mecp2tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (33 available)
Tg(Slc32a1-cre)2.1Hzo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• around 50% of mutant mice die by 26 weeks

growth/size/body
• mice exhibit a period of rapid weight loss preceding death; initial weight gain is normal

behavior/neurological
N
• at 12 weeks of age, mice show similar responses to controls in thermal nociception assays, indicating that the self-injury observed is not due to impaired nociception
• mice display no anxiety-like phenotypes, indicating that hypoactivity or altered social behavior does not result from increased anxiety
• animals show no increased interest in a novel object than controls at 11-12 weeks
• mice recognize and habituate to a novel vanilla odorant; mutants did spend more time sniffing the novel scent than controls (possible manifestation of repetitive behavior) on the first day, but show no differences on the second day
• in a Morris water maze paradigm, animals show a similar rate of learning to control during the 4 training days, but have difficulty locating the platform during the probe trial
• time spent grooming is 300% greater than in control mice; excessive grooming leads to fur loss and epidermal lesions in group- and single-housed mice
• mice have impaired maximum acoustic startle response than controls to 120 dB at 8 weeks
• after 5 weeks of age, mice show repetitive behavior such as hindlimb clasping
• at 5 weeks, mice show increased numbers of footslips on a wire grid and impaired dowel walk at 9 weeks
• mice have a shorter latency to fall on an accelerating rotarod at 19 weeks
• at 9 weeks, mice show decreased time wire hang time prior to falling and reduce forelimb grip strength compared to controls
• there is a trend to reduced activity observed at 12 weeks, while 19-week old mice are hypoactive
• male mice begin to show repetitive behaviors after 5 weeks of age such as forelimb stereotypies similar to the mid-line hand-wringing that characterizes Rett syndrome in humans
• animals display a greater tendency to place their nose in the same hole 2 or more sequential times in a holeboard assay for head-dipping stereotypy
• mice are poor nest builders, possibly due to social behavior alterations or to forelimb apraxia at 13 weeks
• mice spend more time showing directed interest (sniffing, pawing, rearing) near the novel partner mouse than displayed by controls in a 3-chamber assay of social interaction at 12-13 weeks

nervous system
N
• miniature excitatory postsynaptic current quantal size and frequency are similar to controls
• paired pulse ratio is not significantly altered in neurons
• non-seizure hyperexcitability discharges are frequently observed in cultured neurons, but no electrographic seizures are seen
• impaired LTP induced by theta-burst stimulation of Schaffer collaterals is detected
• amplitude and charge of mIPSCs from layer 2/3 pyramidal neurons of the somatosensory cortex are reduced; no change in frequency is observed
• similar results are observed in autaptic GABAergic striatal neurons
• mice show an increased prepulse inhibition at 78 and 82 dB prepulses at 8 weeks

respiratory system
• coinciding with weight loss, mice display a 42% reduction in tidal volume (and 45% reduction in minute volume)
• severe respiratory dysfunction is coincident with weight loss
• mice display frequent apneas of greater than 0.4 second durations, coincident with weight loss





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory