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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adarb1tm1.1Skwa
targeted mutation 1.1, Shin Kwak
MGI:4840554
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Gria2tm1.1Phs/Gria2tm1.1Phs
Tg(SLC18A3-cre)KMisa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4843115
cn2
Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Tg(SLC18A3-cre)KMisa/0
involves: C57BL/6 MGI:4843114


Genotype
MGI:4843115
cn1
Allelic
Composition
Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Gria2tm1.1Phs/Gria2tm1.1Phs
Tg(SLC18A3-cre)KMisa/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation (0 available); any Adarb1 mutation (7 available)
Gria2tm1.1Phs mutation (1 available); any Gria2 mutation (46 available)
Tg(SLC18A3-cre)KMisa mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal motor function until 6 months of age

nervous system
N
• motor neuron death observed in Adarb1tm1.1Skwa/Adarb1tm1.1Skwa Tg(SLC18A3-cre)KMisa mice is prevented




Genotype
MGI:4843114
cn2
Allelic
Composition
Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Tg(SLC18A3-cre)KMisa/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation (0 available); any Adarb1 mutation (7 available)
Tg(SLC18A3-cre)KMisa mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice survive 82 weeks compared with 105 weeks for wild-type mice

nervous system
• ramified axons innervate more than one neuromuscular junction unlike in wild-type mice
• ramified axons innervate more than one neuromuscular junction unlike in wild-type mice
• mice exhibit fewer large neurons in the facial and hypoglossal nerves compared to in wild-type mice
• however, the number of neurons in the oculomotor nerve is normal
• mice exhibit fewer large neurons compared to in wild-type mice
• mice exhibit fewer large neurons compared to in wild-type mice
• the number of myelinated axons in the ventral roots is decreased compared to in wild-type mice
• between 1 and 2 months of age and slowly decreasing beyond 1 year of age

behavior/neurological
N
• mice exhibit normal withdrawal response to noxious stimuli
• rotarod performance decreases from 5 weeks through 5 to 6 months of age and further after 18 months in comparison with wild-type mice
• of the hind limb and tail
• of the hind limb
• mice are hypokinetic unlike wild-type mice

muscle
• skeletal muscles exhibit pyknotic nuclear clumps unlike in wild-type mice

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis DOID:332 OMIM:PS105400
J:164294





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory