Mouse Genome Informatics
cn1
    Tg(CAG-RPS19*R62W)#Dmb/0
Tg(Prnp-GFP/cre)1Blw/0

involves: 129S6/SvEvTac * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice rarely survive beyond weaning
• fewer than expected mice are present at E13.5

hematopoietic system
• at E13.5, the number of R4 and R5 cells is increased compared to in wild-type mice
• at E13.5, the number of R2 cells is decreased 4-fold in the bone marrow and 40-fold in the spleen compared to in wild-type mice
• R3 cells contain 2 nuclei unlike in wild-type mice
• more R4 and R5 cells are uncondensed, nucleated, and poorly hemoglobinized compared to in wild-type mice
• the number of R3 cells in G1 is reduced while the number of cells in the G2/M phase is increased compared to in wild-type mice
• at 4 to 6 weeks, the number of Ter119+ erythroid cells is increased 1.3-fold in the bone marrow and 3.7-fold in the spleen compared to in wild-type mice
• erythroid maturation is inhibited compared to in wild-type mice
• at 4 to 6 weeks
• at 4 to 6 weeks
• severe at E13.5; mild at 4 to 6 weeks
• the number of BFU-E and CFU-E are decreased in fetal liver and bone marrow compared to in wild-type mice
• 10-fold fewer at 4 to 6 weeks

growth/size

Mouse Models of Human Disease
OMIM IDRef(s)
Diamond-Blackfan Anemia 1; DBA1 105650 J:165876