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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkaa1tm1.1Sjm
targeted mutation 1.1, Sean J Morrison
MGI:4836199
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA * SJL MGI:4840217


Genotype
MGI:4840217
cn1
Allelic
Composition		 Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1tm1.1Sjm mutation (1 available); any Prkaa1 mutation (42 available)
Prkaa2tm1.1Sjm mutation (1 available); any Prkaa2 mutation (33 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:165090 )
N
• hematopoietic stem cells numbers and long-term multi-lineage reconstitution function are normal in pIpC-treated mice
decreased hematopoietic stem cell number ( J:165090 )
• 2-fold in pIpC treated mice

cellular
cellular phenotype ( J:165090 )
N
• hematopoietic stem cells from pIpC treated mice exhibit normal reactive oxygen species or aneuploidy in culture
increased mitochondrial fission ( J:165090 )
• in the hematopoietic stem cells of pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory