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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prkaa1tm1.1Sjm
targeted mutation 1.1, Sean J Morrison
MGI:4836199
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * SJL MGI:4840217


Genotype
MGI:4840217
cn1
Allelic
Composition
Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1tm1.1Sjm mutation (1 available); any Prkaa1 mutation (35 available)
Prkaa2tm1.1Sjm mutation (1 available); any Prkaa2 mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• hematopoietic stem cells numbers and long-term multi-lineage reconstitution function are normal in pIpC-treated mice
• 2-fold in pIpC treated mice

cellular
N
• hematopoietic stem cells from pIpC treated mice exhibit normal reactive oxygen species or aneuploidy in culture
• in the hematopoietic stem cells of pIpC-treated mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory