All Phenotypes Ppcd1 MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppcd1
posterior polymorphous corneal dystrophy 1
MGI:4830871

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppcd1/Ppcd1	D2.129-Ppcd1	MGI:5912182
ht2	Ppcd1/+	D2.129-Ppcd1	MGI:4830893
ht3	Ppcd1/+	(D2.129-Ppcd1 x C57BL/6)F1	MGI:4830890
ht4	Ppcd1/+	(D2.129-Ppcd1 x FVB/N)F1	MGI:4830891
ht5	Ppcd1/+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4830892
cx6	Kat14^{tm1a(KOMP)Wtsi}/Ppcd1	D2.Cg-Kat14^{tm1a(KOMP)Wtsi}/Ppcd1	MGI:5912187
cx7	Kat14^{tm1d(KOMP)Wtsi}/Ppcd1	D2.Cg-Kat14^{tm1d(KOMP)Wtsi}/Ppcd1	MGI:5912185
cx8	Dzank1^{tm1a(KOMP)Wtsi}/Ppcd1	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * DBA/2J	MGI:5912189

Allelic Composition	Ppcd1/Ppcd1
Genetic Background	D2.129-Ppcd1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:164007 )

• no live pups are recovered

Allelic Composition	Ppcd1/+
Genetic Background	D2.129-Ppcd1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Eye abnormalities in Ppcd1/0 mice

vision/eye

abnormal iridocorneal angle ( J:164007 )

• at P3, the cells in the iridocorneal angle are more densely packed than in wild-type mice

• at P5, the iridocorneal angle is occluded compared to in wild-type mice

• however, the irridocorneal angle is normal immediately after birth

abnormal trabecular meshwork morphology ( J:164007 )

• the trabecular meshwork of the eye is occluded by multilayered, stratified endothelial cells that exhibit an epithelial morphology, are visible in the iridocorneal angle and on the posterior surface of the cornea and anterior surface of the iris, and migrate onto the central cornea unlike in wild-type mice

abnormal cornea morphology ( J:164007 )

• mice exhibit inappropriate cytokeratin AE1/AE3 immunoreactivity in the corneal endothelium and iridocorneal angle, extending onto the anterior surface of the iris and posterior surface of the cornea unlike in wild-type mice

corneal vascularization ( J:164007 )

anterior iris synechia ( J:164007 )

decreased cornea thickness ( J:164007 )

• in some mice

corneal opacity ( J:164007 )

corneal scarring ( J:164007 )

enlarged eye anterior chamber ( J:164007 )

abnormal lens morphology ( J:164007 )

• mice exhibit lens subluxation and proliferation of cells over the surface of the lens unlike wild-type mice

abnormal eye size ( J:164007 )

• eye diameter is increased compared to in wild-type mice

phthisis bulbi ( J:164007 )

cardiovascular system

corneal vascularization ( J:164007 )

Allelic Composition	Ppcd1/+
Genetic Background	(D2.129-Ppcd1 x C57BL/6)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

enlarged eye anterior chamber ( J:164007 )

macrophthalmia ( J:164007 )

• Background Sensitivity: 38% of mice exhibit enlarged eyes in an F1 cross to C57BL/6 compared with 44% of mice in F1 cross to FVB/N

Allelic Composition	Ppcd1/+
Genetic Background	(D2.129-Ppcd1 x FVB/N)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

enlarged eye anterior chamber ( J:164007 )

macrophthalmia ( J:164007 )

• Background Sensitivity: 44% of mice exhibit enlarged eyes in an F1 cross to FVB/N compared with 38% of mice in an F1 cross to C57BL/6

Allelic Composition	Ppcd1/+
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Eye abnormalities in Ppcd1/0 mice

vision/eye

vision/eye phenotype ( J:164007 )

N	• mice backcrossed to C57BL/6 for 3 generations do not exhibit the Corneal Dystrophy, Posterior Polymorphous, 1 (PPCD1) phenotype

posterior iris synechia ( J:164007 )

abnormal cornea morphology ( J:164007 )

• mice exhibit corneal haze, neovascularization, ulcers, and scarring unlike wild-type mice

corneal vascularization ( J:164007 )

anterior iris synechia ( J:164007 )

cornea ulcer ( J:164007 )

corneal opacity ( J:164007 )

corneal scarring ( J:164007 )

enlarged eye anterior chamber ( J:164007 )

• the anterior chamber is deep and enlarged compared to in wild-type mice

abnormal lens morphology ( J:164007 )

• mice exhibit lens subluxation unlike wild-type mice

phthisis bulbi ( J:164007 )

cardiovascular system

corneal vascularization ( J:164007 )

Allelic Composition	Kat14^{tm1a(KOMP)Wtsi}/Ppcd1
Genetic Background	D2.Cg-Kat14^{tm1a(KOMP)Wtsi}/Ppcd1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat14^{tm1a(KOMP)Wtsi} mutation (2 available); any Kat14 mutation (73 available)
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:236024 )

• no mice are present when survival is scored at weaning

Allelic Composition	Kat14^{tm1d(KOMP)Wtsi}/Ppcd1
Genetic Background	D2.Cg-Kat14^{tm1d(KOMP)Wtsi}/Ppcd1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat14^{tm1d(KOMP)Wtsi} mutation (0 available); any Kat14 mutation (73 available)
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:236024 )

• no mice are present when survival is scored at weaning

Allelic Composition	Dzank1^{tm1a(KOMP)Wtsi}/Ppcd1
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dzank1^{tm1a(KOMP)Wtsi} mutation (1 available); any Dzank1 mutation (43 available)
Ppcd1 mutation (1 available); any Ppcd1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:236024 )

• 50% of mice die prior to birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23