Mouse Genome Informatics
hm1
    Slc6a9tm1Veul/Slc6a9tm1Veul
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype


Mouse Genome Informatics
cn2
    Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(Syn1-cre)671Jxm/?

involves: 129P2/OlaHsd * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
muscle
N
• no hypotonia (J:161993)

behavior/neurological
N
• no motor defects seen in open field or rotarod tests (J:161993)

nervous system
• GlyT1 specific uptake of glycine by hippocampal membranes is reduced 50%


Mouse Genome Informatics
cn3
    Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(EIIa-cre)C5379Lmgd/?

involves: 129P2/OlaHsd * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• die within 8 hours of birth

muscle

behavior/neurological


Mouse Genome Informatics
cn4
    Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(Gfap-cre)2Brn/?

involves: 129P2/OlaHsd * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• hypotonic phenotype leads to premature death
• frequency of deaths peaks at around 3 days of age
• 20% of mice have a normal life span

muscle
• 80% of homozygotes show a strong hypotonic phenotype
• onset from day 1 through 10 days of age
• 20% of mice develop no phenotype