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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc6a9tm1Veul
targeted mutation 1, Volker Eulenburg
MGI:4818447
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc6a9tm1Veul/Slc6a9tm1Veul involves: 129P2/OlaHsd MGI:4818485
cn2
Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(Syn1-cre)671Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4818488
cn3
Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(EIIa-cre)C5379Lmgd/?
involves: 129P2/OlaHsd * FVB/N MGI:4818487
cn4
Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(Gfap-cre)2Brn/?
involves: 129P2/OlaHsd * FVB/N MGI:4818489


Genotype
MGI:4818485
hm1
Allelic
Composition
Slc6a9tm1Veul/Slc6a9tm1Veul
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9tm1Veul mutation (0 available); any Slc6a9 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4818488
cn2
Allelic
Composition
Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(Syn1-cre)671Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9tm1Veul mutation (0 available); any Slc6a9 mutation (7 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• no hypotonia

behavior/neurological
N
• no motor defects seen in open field or rotarod tests

nervous system
• GlyT1 specific uptake of glycine by hippocampal membranes is reduced 50%




Genotype
MGI:4818487
cn3
Allelic
Composition
Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9tm1Veul mutation (0 available); any Slc6a9 mutation (7 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 8 hours of birth

muscle

behavior/neurological




Genotype
MGI:4818489
cn4
Allelic
Composition
Slc6a9tm1Veul/Slc6a9tm1Veul
Tg(Gfap-cre)2Brn/?
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9tm1Veul mutation (0 available); any Slc6a9 mutation (7 available)
Tg(Gfap-cre)2Brn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• hypotonic phenotype leads to premature death
• frequency of deaths peaks at around 3 days of age
• 20% of mice have a normal life span

muscle
• 80% of homozygotes show a strong hypotonic phenotype
• onset from day 1 through 10 days of age
• 20% of mice develop no phenotype





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory