Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Add3tm1.2Llp mutation
(1 available);
any
Add3 mutation
(42 available)
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cardiovascular system
 N |
• pulse rate, systolic, diastolic and mean arterial pressure assessed in females is normal
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Allelic
Composition |
Add3tm1.2Llp/Add3tm1.2Llp
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Genetic
Background |
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Add3tm1.2Llp mutation
(1 available);
any
Add3 mutation
(42 available)
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normal phenotype
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• hematological values, osmotic fragility, and ektacytometry are all normal, red blood cells are normal in size and shape, and no change is found in the relative amounts of key membrane proteins in red blood cells, including alpha and beta adducin
• although there is a decrease by approximately 70% of the amount of alpha adducin in platelets, the bleed time, whole blood aggregation time, mean platelet volume, platelet numbers, structure and shape are all normal
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hematopoietic system
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• additional disruption of the gamma adducin gene does not exacerbate the phenotype of the beta adducin knockout and the changes in hematological values, altered red blood cell shapes and size, reticulocytosis, decreased hematocrit, and increased red blood cell fragility are the same, although the alpha adducin levels in red blood cell membranes is reduced to an almost undetectable level and the level in brain and spleen is reduced to half normal levels
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• the increase in red blood cell fragility as assessed by osmotic lysis and ektacytometry is the same as in beta adducin knockouts
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Analysis Tools
