Add3^tm1.2Llp
Targeted Allele Detail

Summary

• Symbol: Add3^tm1.2Llp
• Name: adducin 3; targeted mutation 1.2, Luanne Peters
• MGI ID: MGI:4462017
• Synonyms: gamma-add^{deltaex2deltaneo}
• Gene: Add3 Location: Chr19:53128874-53235518 bp, + strand Genetic Position: Chr19, 47.18 cM
• Alliance: Add3^tm1.2Llp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161920
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed exon 2 was excised from Add3^tm1.1Llp by mating with mice expressing cre recombinase. Western blotting confirmed the absence of the protein in the spleen. (J:161920)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Add3 Mutation: 42 strains or lines available

References

• Original: J:161920 Sahr KE, et al., Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells. Am J Hematol. 2009 Jun;84(6):354-61
• All: 1 reference(s)