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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm5(ACTB-tTA)Luo
targeted mutation 5, Liqun Luo
MGI:4461408
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+ involves: 129S1/Sv * 129X1/SvJ MGI:4461430
cn2
Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0
Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL MGI:5643754


Genotype
MGI:4461430
ht1
Allelic
Composition
Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(ACTB-tTA)Luo mutation (4 available); any Gt(ROSA)26Sor mutation (741 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5643754
cn2
Allelic
Composition
Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0
Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(ACTB-tTA)Luo mutation (4 available); any Gt(ROSA)26Sor mutation (741 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• shortened head
• mice are smaller at 6 months of age, with average mass reduced by 30%
• however, mice maintained in the presence of doxycycline exhibit normal skeletal phenotypes
• shortening of the trunk in 6 and 10 week old mice

skeleton
• reduction in length/width ratio of the skull
• the extracellular content of collagen II is reduced in growth plates
• the collagenous matrix in growth plates lacks structural continuity and the longitudinal septa are irregularly thickened
• polarity of proliferating chondrocytes and periarticular chondrocytes in the growth plates is not clearly defined
• the parallel organization of primary cilia in chondrocytes of the growth plates of newborns is not clearly established and the uniform pattern of primary cilia alignment in growth plates of 10 week old mice is not apparent
• 10 week old mice show irregular distribution of collagen X-rich matrix in the hypertrophic zones
• tibial growth plates show disorganized columnar chondrocytes whose continuity of the typical palisade-like arrangement is often interrupted by extended areas in which chondrocytes are absent
• vertebrae are shorter and wider
• diameter of collagen fibrils in the growth plates is small
• polarity of proliferating chondrocytes and periarticular chondrocytes in the growth plates is not clearly defined
• percent of chondrocytes undergoing division is lower in newborn and 10-week old mutants than in controls, indicating decreased proliferation
• an increase in BiP content indicates that chondrocytes are undergoing endoplasmic reticulum stress

cellular
• aberrant organization of primary cilia in chondrocytes of growth plates
• length of cilia present in growth plate chondrocytes is reduced

craniofacial
• reduction in length/width ratio of the skull

limbs/digits/tail

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spondyloepiphyseal dysplasia congenita DOID:14789 OMIM:183900
J:216945





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory