Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe
Transgene Detail

Summary

• Symbol: Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe
• Name: transgene insertion, Andrzej Fertala
• MGI ID: MGI:5643753
• Synonyms: R992C^ProGFP
• Transgene: Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe Location: unknown
• Alliance: Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Col2a1

• Mutation details: The collagen alpha1(II) chain containing an R992C amino acid substitution is under the control of the tetracycline response element-controlled cytomegalovirus (TRE-CMV) promoter. Two lines were created and this line carrying two copy numbers was analyzed. The pound symbol (#) is used because the line is not specified. (J:216945)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:216945 Arita M, et al., Mechanisms of Aberrant Organization of Growth Plates in Conditional Transgenic Mouse Model of Spondyloepiphyseal Dysplasia Associated with the R992C Substitution in Collagen II. Am J Pathol. 2015 Jan;185(1):214-29
• All: 3 reference(s)