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Allele Symbol Allele Name Allele ID |
Tg(Igh-V-CD40lg)#Tsub transgene insertion, Takeshi Tsubata MGI:4461029 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• one-third to one-half of 12- to 14-mo-old mice show production of autoantibodies
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• one-third to one-half of 12- to 14-mo-old mice show production of autoantibodies
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• one-third to one-half of 12- to 14-mo-old mice show production of autoantibodies
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• approximately half of mice have a diffuse deposition of PAS-positive substance and hypercellularity in glomeruli
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• the level of urine protein is elevated in 12- to 14-mo-old
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• the level of urine protein is elevated in 12- to 14-mo-old
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• approximately half of mice have a diffuse deposition of PAS-positive substance and hypercellularity in glomeruli
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:128824 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• epithelial hyperplasia with glandular elongation in whole colon and ileum
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• crypt hyperplasia within the ileum
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• thicked wall
• mononuclear cells in colon significantly increased in 15-wk-old mice
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• goblet cell depletion in whole colon
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• severe colitis in 15-wk-old mice, mostly B220+ cells and CD8+ cells
• extensive leukocytic infiltrates were seen in the lamina propria; and submucosa and, to a lesser
degree, in the muscularis, serosa, and mesentery
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• significant weight loss until 20 wk of age
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• increased mononuclear proliferation in spleen
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• mononuclear cells in spleen significantly increased in 15-wk-old mice
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• significantly increased by 4 fold
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• significantly increased by 5 fold
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• increased mononuclear proliferation in spleen
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• severe colitis in 15-wk-old mice, mostly B220+ cells and CD8+ cells
• extensive leukocytic infiltrates were seen in the lamina propria; and submucosa and, to a lesser
degree, in the muscularis, serosa, and mesentery
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• mononuclear cells in spleen significantly increased in 15-wk-old mice
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• significantly increased by 4 fold
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• significantly increased by 5 fold
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• hyperplastic bronchus-associated lymphoid tissue in lungs of half of the mice
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• enlarged mesenteric lymph nodes
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• by lamina propria CD4 T cells stimulated in culture
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• IgM autoantibodies that reacts with colon crypt epithelium
• IgG autoantibodies that show a strong reaction with surface epithelium of the colon
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• 50% of mice
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• goblet cell depletion in whole colon
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• crypt hyperplasia within the ileum
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• 50% of mice
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• goblet cell depletion in whole colon
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• increased mononuclear proliferation in spleen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease | DOID:0050589 |
OMIM:PS266600 |
J:89855 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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