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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hif1antm1.2Rsjo
targeted mutation 1.2, Randall S Johnson
MGI:4459899
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo B6.129-Hif1antm1.2Rsjo MGI:4459903
cx2
Hif1atm1Rsjo/Hif1atm1Rsjo
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Vhltm1Jae/Vhltm1Jae
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4459906
cx3
Hif1atm1Rsjo/Hif1atm1Rsjo
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
involves: 129S1/Sv * 129X1/SvJ MGI:4459911


Genotype
MGI:4459903
hm1
Allelic
Composition
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic
Background
B6.129-Hif1antm1.2Rsjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1antm1.2Rsjo mutation (0 available); any Hif1an mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increase in cellular ATP levels

homeostasis/metabolism
• on a 60% fat diet, measuring after fasting
• after 14 hr of exposure to hypoxia levels of plasma erythropoietin are reduced
• on a standard and 60% fat diet
• on standard and 60% fat diet
• on standard and 60% fat diet
• increased evolution of carbon dioxide under normoxic conditions on standard and 60% fat diet
• elevated consumption of oxygen under normoxic conditions on standard and 60% fat diet
• partial pressure of oxygen and oxygen saturation are elevated in arterial blood gas analysis at normoxia
• on a normal and 60% fat diet
• 20% increase in heat production
• increased heat prodcution on a 60% fat diet

cardiovascular system
• in resting 2-month-old mice under normoxic condition

respiratory system
• minute volume (Vi) shows that the greatest discrepancy between wild-type and mutant mice at normoxia
• at normoxia
• elevation in frequency of respiration only during hypoxia

behavior/neurological

growth/size/body
• at birth and throughout life
• less weight gain than wild-type on a 60% fat diet

adipose tissue

liver/biliary system
• on a 60% fat diet
• less lipid droplets in liver of mice on a 60% fat diet

muscle
• quadriceps weight is decreased on a 60% fat diet

limbs/digits/tail
• quadriceps weight is decreased on a 60% fat diet




Genotype
MGI:4459906
cx2
Allelic
Composition
Hif1atm1Rsjo/Hif1atm1Rsjo
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Vhltm1Jae/Vhltm1Jae
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1antm1.2Rsjo mutation (0 available); any Hif1an mutation (15 available)
Hif1atm1Rsjo mutation (0 available); any Hif1a mutation (48 available)
Vhltm1Jae mutation (2 available); any Vhl mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• proliferation of MEFs after 48 hours of culturing in normoxia or hypoxia conditions is normal




Genotype
MGI:4459911
cx3
Allelic
Composition
Hif1atm1Rsjo/Hif1atm1Rsjo
Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1antm1.2Rsjo mutation (0 available); any Hif1an mutation (15 available)
Hif1atm1Rsjo mutation (0 available); any Hif1a mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• of MEFs after 48 hours of culturing in normoxia or hypoxia conditions





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory