Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NbeaTg(GH1)240BNec mutation
(0 available);
any
Nbea mutation
(139 available)
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mortality/aging
nervous system
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• mice exhibit normal central nervous system morphology, neuromuscular synapses, transmission of action potentials along axons in muscle regions, and spontaneous neurotransmitter release
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• the phrenic nerve fails to exhibit miniature endplate potential (mepp) when stimulated at 0.5-1 Hz unlike similarly treated wild-type nerves
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behavior/neurological
homeostasis/metabolism
adipose tissue
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• at birth, mice exhibit an enlargement of the intrescapular brown adipose fat depot compared to wild-type mice
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muscle
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• phrenic nerve stimulation failed to produce twitch or tetanic muscle contractions unlike in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NbeaTg(GH1)240BNec mutation
(0 available);
any
Nbea mutation
(139 available)
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growth/size/body
behavior/neurological
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• in the contextual fear conditioning test, mutants show increased percentage of freezing when exposed to the same context after aversive footshock conditioning
• however, anxiety-related exploration in the elevated maze is normal
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• during the acquisition trials of the Morris water maze, females travel an overall increased distance
• in the first probe trial of the Morris water maze, females fail to show a preference for the target quadrant, indicating lack of spatial preference
• in the second probe trial of the Morris water maze, females do develop a preference for the target quadrant but it is less pronounced than in wild-type mice
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• increase in self-grooming behavior after snout is sprayed with water mist
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• females show diminished horizontal ambulatory activity during night-day transition
• however, exploratory behavior is normal
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• in the social exploration test, females show increased overall ambulatory activity in the forced presence of two stranger mice in the center of the arena
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• the first session (the social preference trial) of the sociability preference for social novelty test, females spend equal time in both the empty chamber and the chamber containing an unfamiliar mouse unlike controls that prefer the chamber with the mouse
• females spend less time interacting with the unfamiliar mouse than controls, with actual social interaction only during the first period after exposure to the new chambers
• however, in the second session (preference for social novelty), females show preference for the unfamiliar mouse similarly to controls, indicating ability to distinguish a novel mouse from a previously encountered mouse
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nervous system
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• brain weight is increased relative to the body size in females at 12 weeks of age
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• enhancement of long-term potentiation in CA1 area of the hippocampus
• however, females exhibit normal basic synaptic excitability, presynaptically mediated short-term plasticity, and sensorimotor gating
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NbeaTg(GH1)240BNec mutation
(0 available);
any
Nbea mutation
(139 available)
|
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endocrine/exocrine glands
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• mice exhibit small body size compared with wild-type mice due to selective inhibition of postnatal pituitary development
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growth/size/body
nervous system
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• mice exhibit small body size compared with wild-type mice due to selective inhibition of postnatal pituitary development
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Analysis Tools