Nbea^{Tg(GH1)240BNec}
Transgenic Allele Detail

Summary

• Symbol: Nbea^{Tg(GH1)240BNec}
• Name: neurobeachin; transgene insertion 240B, Nancy E Cooke
• MGI ID: MGI:4452356
• Synonyms: -0.5hGH, GH240B, Nbea^Tr
• Gene: Nbea Location: Chr3:55532616-56091122 bp, - strand Genetic Position: Chr3, 26.61 cM
• Alliance: Nbea^{Tg(GH1)240BNec} page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Null/knockout)
• Mutation: Insertion
• Mutation details: Six copies of the transgene, containing the native 500 bp EcoRI fragment of the human gene, inserted into intron 1. The absence of the insertion locus transcript expression was confirmed by northern blot and RNase protection assays on whole brain extracts from homozygous mice. Trace levels of the transgene transcript expression were detected by high cycle number RT-PCR studies. (J:128767, J:129701)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbea Mutation: 139 strains or lines available

References

• Original: J:129701 Jones BK, et al., The human growth hormone gene is regulated by a multicomponent locus control region. Mol Cell Biol. 1995 Dec;15(12):7010-21
• All: 7 reference(s)