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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tgm5tm2a(KOMP)Wtsi
targeted mutation 2a, Wellcome Trust Sanger Institute
MGI:4451573
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tgm5tm2a(KOMP)Wtsi/Tgm5tm2a(KOMP)Wtsi involves: C57BL/6N MGI:5896354
cn2
Grhl3tm1Jane/Grhl3tm3.1Jane
Tgm5tm2a(KOMP)Wtsi/Tgm5tm2a(KOMP)Wtsi
Tg(KRT14-cre)8Brn/0
involves: 129S1/Sv * C57BL/6N * FVB/N MGI:5896358


Genotype
MGI:5896354
hm1
Allelic
Composition
Tgm5tm2a(KOMP)Wtsi/Tgm5tm2a(KOMP)Wtsi
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm5tm2a(KOMP)Wtsi mutation (1 available); any Tgm5 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• no evidence of skin barrier dysfunction was seen at E18.5 or 6 weeks of age
• no signs of skin peeling were seen unlike in human patients with TGM5 mutations




Genotype
MGI:5896358
cn2
Allelic
Composition
Grhl3tm1Jane/Grhl3tm3.1Jane
Tgm5tm2a(KOMP)Wtsi/Tgm5tm2a(KOMP)Wtsi
Tg(KRT14-cre)8Brn/0
Genetic
Background
involves: 129S1/Sv * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1Jane mutation (1 available); any Grhl3 mutation (53 available)
Grhl3tm3.1Jane mutation (1 available); any Grhl3 mutation (53 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Tgm5tm2a(KOMP)Wtsi mutation (1 available); any Tgm5 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• present in expected numbers at E18.5 and 6 weeks of age

integument
N
• no evidence of skin barrier dysfunction was seen





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory