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Allele Symbol Allele Name Allele ID |
Ppp1r14ctm1Uhl targeted mutation 1, George R Uhl MGI:4450989 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice infected with the mouse-adapted SARS-CoV MA15
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Coronavirus infectious disease | DOID:0080599 | J:288523 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are born
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| N |
• mice exhibit normal general learning and motor function
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• following naloxone-precipitated morphine withdrawal, female mice on the original line with the Oprm1 allele from 129S6/SvEvTac exhibit less jumping than males unlike wild-type or recombinant mice the Oprm1 allele from C57BL/6
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• mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
• however, a recombinant line with the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
• in a hot plate assay, recombinant mice with an Oprm1 allele from C57BL/6 exhibit faster development of morphine tolerance compared with wild-type mice
• recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
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• recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
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• mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
• however, a recombinant line with the mutant allele and the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• recombinant mice with the Oprm1 allele from C57BL/6 exhibit an intermediate rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type and homozygous mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
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• recombinant mice with the Oprm1 allele from C57BL/6 exhibit an intermediate rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type and homozygous mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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