About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppp1r14ctm1Uhl
targeted mutation 1, George R Uhl
MGI:4450989
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ppp1r14ctm1Uhl/Ppp1r14ctm1Uhl B6;129S6-Ppp1r14ctm1Uhl/J MGI:6433773
hm2
Ppp1r14ctm1Uhl/Ppp1r14ctm1Uhl involves: 129S6/SvEvTac * C57BL/6J MGI:4451190
ht3
Ppp1r14ctm1Uhl/Ppp1r14c+ involves: 129S6/SvEvTac * C57BL/6J MGI:4451191


Genotype
MGI:6433773
hm1
Allelic
Composition
Ppp1r14ctm1Uhl/Ppp1r14ctm1Uhl
Genetic
Background
B6;129S6-Ppp1r14ctm1Uhl/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r14ctm1Uhl mutation (1 available); any Ppp1r14c mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice infected with the mouse-adapted SARS-CoV MA15 exhibit more weight loss than wild-type mice and a moderate, but insignificant, increase in viral titers

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:288523




Genotype
MGI:4451190
hm2
Allelic
Composition
Ppp1r14ctm1Uhl/Ppp1r14ctm1Uhl
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r14ctm1Uhl mutation (1 available); any Ppp1r14c mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are born

behavior/neurological
N
• mice exhibit normal general learning and motor function
• following naloxone-precipitated morphine withdrawal, female mice on the original line with the Oprm1 allele from 129S6/SvEvTac exhibit less jumping than males unlike wild-type or recombinant mice the Oprm1 allele from C57BL/6
• mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
• however, a recombinant line with the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
• in a hot plate assay, recombinant mice with an Oprm1 allele from C57BL/6 exhibit faster development of morphine tolerance compared with wild-type mice
• recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
• recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
• mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
• however, a recombinant line with the mutant allele and the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine




Genotype
MGI:4451191
ht3
Allelic
Composition
Ppp1r14ctm1Uhl/Ppp1r14c+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r14ctm1Uhl mutation (1 available); any Ppp1r14c mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• recombinant mice with the Oprm1 allele from C57BL/6 exhibit an intermediate rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type and homozygous mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
• recombinant mice with the Oprm1 allele from C57BL/6 exhibit an intermediate rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type and homozygous mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/30/2021
MGI 6.17
The Jackson Laboratory