Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Gle mutation
(0 available);
any
Pten mutation
(81 available)
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mortality/aging
embryo
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• failure of axial rotation
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• defects in anterior-posterior patterning
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• absence of overt tissue differentiation
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Allelic Composition |
Ptentm2.1Gle/Pten+
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Genetic Background |
involves: 129S6/SvEvTac * Black Swiss * FVB/N |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Gle mutation
(0 available);
any
Pten mutation
(81 available)
|
|
|
neoplasm
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• mammary intraepithelial neoplasia in females
• females develop large palpable tumors with adenosquamous morphology and a prominent stromal component
• increased coincidence in females of mammary tumor and lymph node neoplasms
• a few males develop high grade mammary intraepithelial neoplasia
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• adenosquamous carcinoma
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• 70.7% of 9 month old mice develop proliferative lesions of the adrenal gland
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• 86.4% of 9 month old mice develop proliferative lesions of the prostate
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• 81.6% of 9 month old mice develop proliferative lesions of the thyroid
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• 55.8% of 9 month old mice develop proliferative lesions of the lymph node
• increased coincidence of lymph node neoplasms and mammary tumors in females
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• 59.5% of 9 month old mice develop proliferative lesions of the thymus
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endocrine/exocrine glands
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• thyroid follicular lesions
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• a few males develop high grade mammary intraepithelial neoplasia
• mammary intraepithelial neoplasia in females
• females develop large palpable tumors with adenosquamous morphology and a prominent stromal component
• increased coincidence in females of mammary tumor and lymph node neoplasms
|
|
• adenosquamous carcinoma
|
|
• 70.7% of 9 month old mice develop proliferative lesions of the adrenal gland
|
|
• 86.4% of 9 month old mice develop proliferative lesions of the prostate
|
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• 59.5% of 9 month old mice develop proliferative lesions of the thymus
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• 81.6% of 9 month old mice develop proliferative lesions of the thyroid
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reproductive system
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• 86.4% of 9 month old mice develop proliferative lesions of the prostate
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• proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia
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integument
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• mammary intraepithelial neoplasia in females
• females develop large palpable tumors with adenosquamous morphology and a prominent stromal component
• increased coincidence in females of mammary tumor and lymph node neoplasms
• a few males develop high grade mammary intraepithelial neoplasia
|
|
• adenosquamous carcinoma
|